Article

Variants in ZFHX3 are associated with atrial fibrillation in individuals of European ancestry.

National Heart, Lung, and Blood Institute's Framingham Heart Study, Framingham, Massachusetts, USA.
Nature Genetics (Impact Factor: 29.65). 09/2009; 41(8):879-81. DOI: 10.1038/ng.416
Source: PubMed

ABSTRACT We conducted meta-analyses of genome-wide association studies for atrial fibrillation (AF) in participants from five community-based cohorts. Meta-analyses of 896 prevalent (15,768 referents) and 2,517 incident (21,337 referents) AF cases identified a new locus for AF (ZFHX3, rs2106261, risk ratio RR = 1.19; P = 2.3 x 10(-7)). We replicated this association in an independent cohort from the German AF Network (odds ratio = 1.44; P = 1.6 x 10(-11); combined RR = 1.25; combined P = 1.8 x 10(-15)).

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Available from: Thor Aspelund, Jul 30, 2015
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    • "Although good progress has been made in the characterisation of factors that cause AF (Camm et al., 2012a,b; Schotten et al., 2011; Wakili et al., 2011), there is still an unmet need for better therapies to prevent incident and recurrent AF (Camm et al., 2012a,b; Kirchhof et al., 2013). Unravelling the mechanisms conveying the genetic basis of atrial fibrillation (Benjamin et al., 2009; Ellinor et al., 2012; Gudbjartsson et al., 2007) is a promising and relatively new avenue to novel preventive and therapeutic targets. Genetically altered murine models are popular tools for the study of molecular disease mechanisms, including of atrial fibrillation. "
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    Progress in Biophysics and Molecular Biology 08/2014; 115(2-3). DOI:10.1016/j.pbiomolbio.2014.07.012 · 3.38 Impact Factor
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    • "The AT-motif binding factor 1/zinc finger homeobox 3 (ATBF1/ ZFHX3) gene encodes a large protein structurally characterized by multiple zinc-finger motifs and four homeodomains [1]. ATBF1 appears to play a role in neuronal differentiation and cell death [2] [3] [4], atrial fibrillation [5] [6], and embryonic development [7]. ATBF1 could be a tumor suppressor in several organs including the prostate, "
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