HIV-related neurocognitive impairment in the HAART era.

Mount Sinai School of Medicine, Department of Neurology, Box 1052, One Gustave L. Levy Place, New York, NY 10029, USA.
Current HIV/AIDS Reports 09/2009; 6(3):146-52. DOI: 10.1007/s11904-009-0020-1
Source: PubMed

ABSTRACT Neurocognitive impairment is common in people living with HIV and AIDS. Prior to highly active antiretroviral therapy (HAART), cognitive impairment primarily affected patients with advanced disease, and was a more rapidly progressive illness. With the use of HAART, cognitive impairment improved, along with the overall health of HIV-positive patients. However, it is still a prevalent problem, even in patients with desirable CD4+ count and undetectable plasma viral load. In this review, we address the nature of HIV-related neurocognitive impairment in the HAART era, including its etiology, pathology, appropriate diagnostic tools for clinical practice and research, and rational treatment approaches.

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