Gold Nanoparticles in Nanomedicine: Preparations, Imaging, Diagnostics, Therapies and Toxicity

Institut des Sciences Moléculaires, UMR CNRS No. 5255, Université Bordeaux I, 33405 Talence Cedex, France.
Chemical Society Reviews (Impact Factor: 33.38). 07/2009; 38(6):1759-82. DOI: 10.1039/b806051g
Source: PubMed

ABSTRACT This critical review provides an overall survey of the basic concepts and up-to-date literature results concerning the very promising use of gold nanoparticles (AuNPs) for medicinal applications. It includes AuNP synthesis, assembly and conjugation with biological and biocompatible ligands, plasmon-based labeling and imaging, optical and electrochemical sensing, diagnostics, therapy (drug vectorization and DNA/gene delivery) for various diseases, in particular cancer (also Alzheimer, HIV, hepatitis, tuberculosis, arthritis, diabetes) and the essential in vitro and in vivo toxicity. It will interest the medicine, chemistry, spectroscopy, biochemistry, biophysics and nanoscience communities (211 references).

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Available from: Elodie Boisselier, Sep 22, 2014
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    • "Silver nanoparticles induce significant toxic effects (Panda et al., 2011; Teodoro et al., 2011). Gold nanoparticles (AuNPs) have attracted much attention in the past decades due to their stability and optical properties (Boisselier and Astruc, 2009). Recent reports on the biological applications of AuNPs focus on the effects of biocompatibility , uptake, and sub-cellular distribution of AuNPs (Patra et al., 2007). "
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    • "In recent years, Au nanoparticles (AuNPs) have been proposed as novel radiosensitizing agents for radiation therapy. In the last decade, AuNPs with different sizes and shapes have become widely available, and their biomedical applications have been extensively explored [5] [6] [7]. AuNPs are generally considered as biocompatible. "
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    ABSTRACT: We report in vitro studies on radiotherapy enhancement of hollow gold nanoparticles (HAuNPs), which feature a 50 nm hollow core and a 30 nm thick polycrystalline shell. A clonogenic cell survival assay was used to assess radiation dose enhancement on breast cancer MDA-MB-231 cells. Cells were cultured in a cell culture solution in which pegylated HAuNPs were added. No cytotoxicity of the HAuNPs was observed at the nanoparticle concentration up to 4.25×109 nanoparticles/ml (350 μM Au concentration). A small animal X-ray irradiator and a clinical linear accelerator were used to irradiate HAuNP-treated and control groups. It shows that the radiation damage to the cells is significantly enhanced when the cells are exposed to HAuNPs. This is the first time that AuNPs with diameter larger than 100 nm has been studied for their radiosensitizing effects. In clinical settings, we envision that HAuNPs could be intratumorally injected into tumors, which is more realistic for practical usage of AuNPs as radiosensitizer than passive accumulation in tumors using the enhanced permeability and retention effect or active targeting. Larger particles are favored for the intratumoral injection approach since larger particles tend to be retained in the injection sites, less likely diffusing into surrounding normal tissues. So, this proof-of-concept evaluation shows a promising potential to use HAuNPs as radiation therapy sensitizer for cancers.
    Journal of Nano Research 05/2015; 32:106-112. DOI:10.4028/ · 0.56 Impact Factor
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    • "The development of antimicrobial surfaces/coatings represents a challenge for the implementation of effective control measures to reduce the incidence of healthcareassociated infections (HAI), which have become a global threat due to the emergence and dissemination of microbial pathogens that are resistant to most or even all antimicrobial agents available for their treatment (extensively drug-resistant – XDR or totally drug-resistant phenotypes) [1]. Nanoparticles (NP) have emerged as promising alternatives to conventional materials in many branches of science and technology [2] [3]. The physical behaviour of silver NP (Ag NP), in particular, could represent a challenge for the creation of antimicrobial surfaces [4] [5]. "
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    ABSTRACT: The recent emergence of bacterial pathogens resistant to most or all available antibiotics is among the major global public health problems. As indirect transmission through contaminated surfaces is a main route of dissemination for most of such pathogens, the implementation of effective antimicrobial surfaces has been advocated as a promising approach for their containment, especially in the hospital settings. However, traditional wet synthesis methods of nanoparticle-based antimicrobial materials leave a number of key points open for metal surfaces: such as adhesion to the surface and nanoparticle coalescence. Here we demonstrate an alternative route, i.e. supersonic cluster beam deposition, to obtain antimicrobial Ag nanoparticle films deposited directly on surfaces. The synthesized films are simple to produce with controlled density and thickness, stable over time, and are shown to be highly bactericidal against major Gram positive and Gram negative bacterial pathogens, including extensively drug-resistant strains. Copyright © 2015. Published by Elsevier Inc.
    Nanomedicine: nanotechnology, biology, and medicine 03/2015; 11(6). DOI:10.1016/j.nano.2015.02.023 · 6.16 Impact Factor
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