ChemInform Abstract: Gold Nanoparticles in Nanomedicine: Preparations, Imaging, Diagnosis, Therapies and Toxicity

Institut des Sciences Moléculaires, UMR CNRS No. 5255, Université Bordeaux I, 33405 Talence Cedex, France.
Chemical Society Reviews (Impact Factor: 33.38). 07/2009; 38(6):1759-82. DOI: 10.1039/b806051g
Source: PubMed


This critical review provides an overall survey of the basic concepts and up-to-date literature results concerning the very promising use of gold nanoparticles (AuNPs) for medicinal applications. It includes AuNP synthesis, assembly and conjugation with biological and biocompatible ligands, plasmon-based labeling and imaging, optical and electrochemical sensing, diagnostics, therapy (drug vectorization and DNA/gene delivery) for various diseases, in particular cancer (also Alzheimer, HIV, hepatitis, tuberculosis, arthritis, diabetes) and the essential in vitro and in vivo toxicity. It will interest the medicine, chemistry, spectroscopy, biochemistry, biophysics and nanoscience communities (211 references).

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Available from: Elodie Boisselier, Sep 22, 2014
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    • "Nanoparticles possess unique mechanical, optical, electrical and magnetic properties [1]. Their application towards wider field of nanotechnology including sensor, nano-medicine, separation sciences, solar cells and catalyst remains marvelous. "
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    ABSTRACT: Increasing knowledge on the biomedical applications of nanoemulsions has necessitated the fundamental understanding behind protein–nanoemulsion interaction. Spectroscopic studies on the binding strategies of biomolecules with serum albumins have been routine for many years to elucidate their binding mechanism cum conformational changes. In the present study, we have investigated the effect of neem oil nanoemulsion of different concentration towards bovine and human serum albumin. Spectroscopic methods such as fluorescence emission, synchronous and three-dimensional spectra, UV–Visible spectroscopy, FTIR and circular dichroism techniques were used. Decrease in fluorescence intensity and controversial hyper-chromicity observed in the UV–Visible spectra of albumins confirmed the ground state complex formation between neem oil nanoemulsion and protein fluorophores. Complex attained remains non-fluorescence and static. Reduced intensity of the peak 1 and peak 2 regions of three-dimensional spectra have recommended the possible effect of nanoemulsion towards the aromatic micro-environment of tryptophan and tyrosine residues. Minor shifts observed in the amide frequency of the FTIR bands at around 1600 cm −1 corresponds to the possibilities of variation in the secondary alpha-helical structures of biomolecules on interface with nanoemulsion. Decrease in the far UV-CD absorbance cum shift in the dichoric band of molecules at 208 and 222 nm has proportionate the loss of alpha-helical structures. Prominent changes observed in the near UV-CD spectra of biomolecules have also suggested the possible alterations towards tryptophan residues of peptide backbone.
    Journal of Molecular Liquids 09/2015; 212:283-290. DOI:10.1016/j.molliq.2015.09.022 · 2.52 Impact Factor
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    • "Silver nanoparticles induce significant toxic effects (Panda et al., 2011; Teodoro et al., 2011). Gold nanoparticles (AuNPs) have attracted much attention in the past decades due to their stability and optical properties (Boisselier and Astruc, 2009). Recent reports on the biological applications of AuNPs focus on the effects of biocompatibility , uptake, and sub-cellular distribution of AuNPs (Patra et al., 2007). "

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    • "In recent years, Au nanoparticles (AuNPs) have been proposed as novel radiosensitizing agents for radiation therapy. In the last decade, AuNPs with different sizes and shapes have become widely available, and their biomedical applications have been extensively explored [5] [6] [7]. AuNPs are generally considered as biocompatible. "
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    ABSTRACT: We report in vitro studies on radiotherapy enhancement of hollow gold nanoparticles (HAuNPs), which feature a 50 nm hollow core and a 30 nm thick polycrystalline shell. A clonogenic cell survival assay was used to assess radiation dose enhancement on breast cancer MDA-MB-231 cells. Cells were cultured in a cell culture solution in which pegylated HAuNPs were added. No cytotoxicity of the HAuNPs was observed at the nanoparticle concentration up to 4.25×109 nanoparticles/ml (350 μM Au concentration). A small animal X-ray irradiator and a clinical linear accelerator were used to irradiate HAuNP-treated and control groups. It shows that the radiation damage to the cells is significantly enhanced when the cells are exposed to HAuNPs. This is the first time that AuNPs with diameter larger than 100 nm has been studied for their radiosensitizing effects. In clinical settings, we envision that HAuNPs could be intratumorally injected into tumors, which is more realistic for practical usage of AuNPs as radiosensitizer than passive accumulation in tumors using the enhanced permeability and retention effect or active targeting. Larger particles are favored for the intratumoral injection approach since larger particles tend to be retained in the injection sites, less likely diffusing into surrounding normal tissues. So, this proof-of-concept evaluation shows a promising potential to use HAuNPs as radiation therapy sensitizer for cancers.
    Journal of Nano Research 05/2015; 32:106-112. DOI:10.4028/ · 0.56 Impact Factor
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