Article

Capecitabine-induced cardiotoxicity: when to suspect? How to manage? A case report.

Cardiology Division, Cardiovascular Department, A. Manzoni Hospital, Lecco, Italy.
Journal of Cardiovascular Medicine (impact factor: 1.51). 10/2009; 10(9):722-6. DOI:10.2459/JCM.0b013e32832bb9b1 pp.722-6
Source: PubMed

ABSTRACT We present a case of capecitabine-induced cardiac toxicity manifested by chest pain, ST-segment elevation and ventricular tachycardia. Symptoms and ECG alterations were completely reversible after withdrawal of the drug. Coronary angiography demonstrated the absence of epicardial coronary spasm. We suggest cardiac monitoring with ECG Holter and effort ECG during the first days of drug administration. Prompt evaluation of chest pain in this setting is of paramount importance.

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Keywords

capecitabine-induced cardiac toxicity manifested
 
cardiac monitoring
 
chest pain
 
Coronary angiography
 
effort ECG
 
epicardial coronary spasm
 
first days
 
paramount importance
 
ventricular tachycardia