Dark chocolate or tomato extract for prehypertension: A randomised controlled trial

Discipline of General Practice, The University of Adelaide, Adelaide, SA 5005, Australia.
BMC Complementary and Alternative Medicine (Impact Factor: 2.02). 02/2009; 9(1):22. DOI: 10.1186/1472-6882-9-22
Source: PubMed


Flavanol-rich chocolate and lycopene-rich tomato extract have attracted interest as potential alternative treatment options for hypertension, a known risk factor for cardiovascular morbidity and mortality. Treatment of prehypertension (SBP 120-139/DBP 80-89 mmHg) may forestall progression to hypertension. However, there has been only limited research into non-pharmacological treatment options for prehypertension. We investigated the effect of dark chocolate or tomato extract on blood pressure, and their acceptability as an ongoing treatment option in a prehypertensive population.
Our trial consisted of two phases: a randomised controlled three-group-parallel trial over 12 weeks (phase 1) followed by a crossover of the two active treatment arms over an additional 12-week period (phase 2). Group 1 received a 50 g daily dose of dark chocolate with 70% cocoa containing 750 mg polyphenols, group 2 were allocated one tomato extract capsule containing 15 mg lycopene per day, and group 3 received one placebo capsule daily over 8 weeks followed by a 4-week washout period. In phase 2 the active treatment groups were crossed over to receive the alternative treatment. Median blood pressure, weight, and abdominal circumference were measured 4-weekly, and other characteristics including physical activity, general health, energy, mood, and acceptability of treatment were assessed by questionnaire at 0, 8 and 20 weeks. We analysed changes over time using a linear mixed model, and one time point differences using Kruskal-Wallis, Fisher's-Exact, or t-tests.
Thirty-six prehypertensive healthy adult volunteers completed the 6-month trial. Blood pressure changes over time within groups and between groups were not significant and independent of treatment. Weight and other characteristics did not change significantly during the trial. However, a marked difference in acceptability between the two treatment forms (chocolate or capsule) was revealed (p < 0.0001). Half of the participants allocated to the chocolate treatment found it hard to eat 50 g of dark chocolate every day and 20% considered it an unacceptable long-term treatment option, whereas all participants found it easy and acceptable to take a capsule each day for blood pressure.
Our study did not find a blood pressure lowering effect of dark chocolate or tomato extract in a prehypertensive population. Practicability of chocolate as a long-term treatment option may be limited. Identifier: ACTRN12609000047291.

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Available from: Oliver R Frank, Oct 07, 2015
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    • "in tomato powder group and in pure lycopene group only a 9% risk was reduced as compared to control. A number of studies observed decrease in blood pressure (BP) with daily oral supplementation of tomato extract or tomato juice [201] [202] [203] [204] [205]. Ried et al. [206] found that lycopene treatment significantly decrease only the systolic blood pressure (SBP), not the diastolic BP (DBP). "
    Lycopene: food sources, potential role in human health and antioxidant effects, Edited by J.R. Bailey, 01/2015: pages 39-89; Nova Science Publishers, Inc. New York., ISBN: 978-1-63117-927-3
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    • "Possible explanations for the lack of significant reduction in blood pressure in the present study are (1) baseline levels of blood pressure, evaluated by ABPM, in our patients were lower than the levels found in others studies and (2) dose of dark chocolate was also lower [9] [19]. Ried et al. (2009) [40] did not find a blood pressure reducing effect of 50 g dark chocolate daily over a period of 8 weeks in a prehypertensive population. "
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    ABSTRACT: Background. Hypertension and excess body weight are important risk factors for endothelial dysfunction. Recent evidence suggests that high-polyphenol dark chocolate improves endothelial function and lowers blood pressure. This study aimed to evaluate the association of chocolate 70% cocoa intake with metabolic profile, oxidative stress, inflammation, blood pressure, and endothelial function in stage 1 hypertensives with excess body weight. Methods. Intervention clinical trial includes 22 stage 1 hypertensives without previous antihypertensive treatment, aged 18 to 60 years and presents a body mass index between 25.0 and 34.9 kg/m(2). All participants were instructed to consume 50 g of chocolate 70% cocoa/day (2135 mg polyphenols) for 4 weeks. Endothelial function was evaluated by peripheral artery tonometry using Endo-PAT 2000 (Itamar Medical). Results. Twenty participants (10 men) completed the study. Comparison of pre-post intervention revealed that (1) there were no significant changes in anthropometric parameters, percentage body fat, glucose metabolism, lipid profile, biomarkers of inflammation, adhesion molecules, oxidized LDL, and blood pressure; (2) the assessment of endothelial function through the reactive hyperemia index showed a significant increase: 1.94 ± 0.18 to 2.22 ± 0.08, P = 0.01. Conclusion.In individuals with stage 1 hypertension and excess body weight, high-polyphenol dark chocolate improves endothelial function.
    International Journal of Hypertension 11/2012; 2012:147321. DOI:10.1155/2012/147321
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    • "An increase of nitric oxide levels maybe the mechanism of BP reduction; furthermore, the other ingredients included in tomato, such as phytoene and phytofluene, may have an important effect on the BP F. Shidfar et al. 292 (Paran et al. 2009), but our study was not designed to evaluate this kind of effect. It is likely that the BP level at the start of treatment (hypertension, prehypertension, normotension) is associated with a treatment's effectiveness (Ried et al. 2009). "
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    ABSTRACT: Tomatoes are a rich source of lycopene, β-carotene, potassium, vitamin C, flavonoids, folate and vitamin E that may provide protection against the development of type 2 diabetic patients, so the present study was undertaken to evaluate the effects of tomato intake on serum glucose, homocysteine, apolipoprotein (apo) B, apoA-I and blood pressure in type 2 diabetic patients. In a quasi-experimental study, 32 type 2 diabetes patients received 200 g raw tomato daily for 8 weeks. Serum glucose enzymatically, apoB and apoA-I immunoturbidometrically and homocysteine by high-performance liquid chromatography were measured at the beginning and end of 8 weeks. There were significant decreases in systolic and diastolic blood pressure and also a significant increase in apoA-I at the end of study compared with initial values (P = 0.0001, P = 0.0001 and P = 0.013, respectively). In conclusion, 200 g raw tomato per day had a favored effect on blood pressure and apoA-I so it might be beneficial for reducing cardiovascular risk associated with type 2 diabetes.
    International Journal of Food Sciences and Nutrition 12/2010; 62(3):289-94. DOI:10.3109/09637486.2010.529072 · 1.21 Impact Factor
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