Article

The effects of different anesthetic agents on short electroretinography protocol in dogs.

Department of Veterinary Medicine, College of Veterinary Medicine, National Chung-Hsing University, Taiwan.
Journal of Veterinary Medical Science (impact factor: 0.85). 07/2009; 71(6):763-8. pp.763-8
Source: PubMed

ABSTRACT The purpose of this article was to investigate the effects of sedatives and general anesthetics, such as tiletamine-zolazepam, medetomidine, and isoflurane on the short ERG protocol. Six healthy mongrel dogs were assessed by a convenient short ERG protocol with the owners' consent. The amplitudes of a-wave and b-wave, as well as the implicit time of ERG under different anesthesia statuses, were recorded and analyzed. The amplitudes of ERG waves were not significantly different between tiletamine-zolazepam and medetomidine groups, except in b-wave after 5 min dark adaptation (140 +/- 42 microV in tiletamine-zolazepam and 101 +/- 32 microV in medetomidine, p<0.01). The amplitude of ERG recorded in isoflurane (5 +/- 3 microV of a-wave and 12 +/- 6 microV of b-wave under light adaptation; 41 +/- 19 microV of b-wave after 1 min dark adaptation; 28 +/- 15 microV of a-wave and 58 +/- 32 microV of b-wave after 5 min dark adaptation) were significantly different from tiletamine-zolazepam (8 +/- 2 microV of a-wave and 24 +/- 9 microV of b-wave under light adaptation; 117 +/- 44 microV of b-wave after 1 min dark adaptation; 59 +/- 18 microV of a-wave and 140 +/- 42 microV of b-wave after 5 min dark adaptation), except in a-wave after 1 min dark adaptation (39 +/- 13 microV in tiletamine-zolazepam and 34 +/- 17 microV in isoflurane). Comment-General anesthesia had significantly lower amplitudes in the dark-adapted group compared with the sedation group. Therefore, tiletamine-zolazepam is a desirable choice for the short ERG protocol in dogs.

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    Article: Effects of common anesthetics on eye movement and electroretinogram
    Govind Nair, bullet Moon, Kim @bullet Tsukasa, Nagaoka @bullet, Darin E Olson, Peter M Thulé, bullet Machelle, T Pardue, Timothy Q Duong
    [show abstract] [hide abstract]
    ABSTRACT: High-resolution magnetic resonance imaging (MRI) provides non-invasive images of retinal anatomy, physiology, and function with depth-resolved laminar resolution. Eye movement and drift, however, could limit high spatial resolution imaging, and anesthetics that minimize eye move-ment could significantly attenuate retinal function. The aim of this study was to determine the optimal anesthetic preparations to minimize eye movement and maximize visual-evoked retinal response in rats. Eye movements were examined by imaging of the cornea with a charge-coupled device (CCD) camera under isoflurane, urethane, ketamine/xylazine, and propofol anesthesia at typical dosages in rats. Com-bination of the paralytic pancuronium bromide with isoflurane or ketamine/xylazine anesthesia was also examined for the eye movement studies. Visual-evoked retinal responses were evaluated using full-field electroretinography (ERG) under isoflurane, ketamine/xylazine, urethane, and ketamine/xylazine ? pancuronium anesthesia in rats. The degree of eye movement, measured as displacement per unit time, Govind Nair and Moon Kim contributed equally to this manuscript.
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Keywords

1 min dark adaptation
 
5 min dark adaptation
 
amplitudes
 
Comment-General anesthesia
 
convenient short ERG protocol
 
dark-adapted group
 
desirable choice
 
different anesthesia statuses
 
dogs
 
ERG waves
 
general anesthetics
 
healthy mongrel dogs
 
implicit time
 
isoflurane
 
light adaptation
 
medetomidine groups
 
owners' consent
 
sedation group
 
short ERG protocol
 
tiletamine-zolazepam