Mixed ovarian large cell neuroendocrine carcinoma, mucinous adenocarcinoma, and teratoma: a report of two cases and review of the literature.
ABSTRACT Large cell neuroendocrine carcinoma of the ovary is a rare recently established entity. Few cases have been reported in the literature, and they are usually associated with another type of surface epithelial tumor. The association of a large cell neuroendocrine carcinoma with a surface epithelial tumor and a teratoma is even rarer, with only two cases previously described. We report the cases of two patients in their fifties who presented with a growing abdominal mass and died of metastatic disease within less than a year. Histological assessment revealed large cell neuroendocrine carcinoma admixed with mucinous adenocarcinoma and teratoma. Different hypotheses regarding the origin of large cell neuroendocrine carcinoma of the ovary are discussed. The immunohistochemical pattern of staining for cytokeratin 7 and cytokeratin 20 suggests that the composite epithelial tumors originated from the pre-existing teratoma.
Article: Malignant Mixed Epithelial Tumour Ovary-Papillary Serous Adenocarcinoma and Malignant Brenner's Tumour: An Exceedingly Rare Neoplasm[show abstract] [hide abstract]
ABSTRACT: Mixed ovarian epithelial carcinoma with an unusual histological pattern can be very difficult to diagnose and a thorough sampling of the specimen is needed to rule out the presence of a dual neoplasm. This case reports a very unusual case of mixed epithelial tumour, moderately differentiated serous papillary adenocarcinoma and malignant Brenner's tumour, in a 65 year old female. She presented with a three month history of abdominal pain. Ultrasound of the abdomen revealed an ovarian mass, for which pan-hysterectomy was performed. Extensive sampling of the tissue revealed a dual neoplasm, serous papillary adenocarcinoma (80%) and malignant Brenner's tumour (20%), with multiple deposits of the former (dominant tumour) on the uterus, the contralateral ovary and on both the fallopian tubes.Journal of Clinical and Diagnostic Research 01/2011; 5:1651-1652.