Article

DNA methyltransferase 3B gene increases risk of early onset schizophrenia.

Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai, PR China.
Neuroscience Letters (impact factor: 2.11). 11/2009; 462(3):308-11. DOI:10.1016/j.neulet.2009.06.085 pp.308-11
Source: PubMed

ABSTRACT Consistent evidence indicated that aberrant DNA methylation may be involved in the development of schizophrenia. DNA methyltransferase 3B (DNMT3B) is the key methyltransferase in DNA methylation regulations. In this study, we investigated the association between DNMT3B polymorphisms and the susceptibility of early onset schizophrenia in Chinese Han population.
Case-control (patients=381 and controls=472) and family based (trios=103) study was performed through genotyping two tag single nucleotide polymorphisms (rs2424908 and rs6119954) covering the whole DNMT3B gene. Single nucleotide polymorphism association and haplotype analysis were performed.
The frequency of G allele of rs6119954 was significantly higher in patients than that in controls (P=0.017). Genotype distribution of rs6119954 was significantly different between patients and controls (P=0.046). A haplotype-wise analysis revealed a higher frequency of the T-G (rs2424908-rs6119954) haplotype in patients than that in controls (P=0.033). In the transmission disequilibrium test analysis, G allele of rs6119954 was preferentially transmitted in the trios (P=0.030).
Our findings indicate that DNMT3B may be a candidate gene for susceptibility to early onset schizophrenia.

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Keywords

aberrant DNA methylation
 
candidate gene
 
Chinese Han population
 
Consistent evidence
 
DNA methylation regulations
 
DNA methyltransferase 3B
 
DNMT3B
 
DNMT3B polymorphisms
 
G allele
 
genotyping
 
haplotype analysis
 
haplotype-wise analysis
 
higher frequency
 
onset schizophrenia
 
schizophrenia
 
Single nucleotide polymorphism association
 
susceptibility
 
T-G
 
transmission disequilibrium test analysis
 
whole DNMT3B gene