Prevalencia de virus de papiloma humano de alto riesgo en el epitelio anal de hombres VIH positivos

Bioquimia 01/2002;
Source: DOAJ

ABSTRACT Existen cerca de 200 tipos distintos de Virus de Papiloma Humano (VPH), de los cuales alrededor de 70 están asociados con neoplasias anogenitales. De ellos, un sub-grupo se encuentra frecuentemente asociado a la formación de lesiones escamosas intraepiteliales y carcinomas, por ello, se ha denominado de "alto" riesgo. Varios reportes han demostrado que los hombres que tienen sexo con hombres (HSH) y que son positivos al VIH, presentan una mayor incidencia de lesiones precursoras y de cáncer anal que aquellos que no lo son. En este trabajo se realizó un estudio con 31 pacientes hombres VIH positivos que tienen sexo con hombres, para determinar la prevalencia de infecciones con VPH. Se utilizó la prueba de captura de híbridos II, que permite la detección de 18 tipos virales distintos. Encontramos una alta prevalencia de VPH en el epitelio anal de estos pacientes, que alcanza casi el 75%. El 58% de los pacientes fue positivo para ambos tipos virales ("alto" y "bajo" riesgo) mediante esta prueba, lo cual indica que un alto porcentaje de estos pacientes presenta infección múltiple de VPH. Este estudio enfatiza la necesidad de hacer la detección oportuna de infecciones de VPH en hombres que tienen sexo con hombres y son VIH positivos.

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