Total PSA and free PSA in patients with severe liver dysfunction

Rama Mittal, Mahendra Singh, Charles Selvaraju, Gourdas Choudhuri

Journal Article: Indian Journal of Urology 01/2003;

Abstract

Objectives: To evaluate the effect of liver diseases in patients, on serum free prostate specific antigen (JPSA) levels, total prostate specific antigen (tPSA) levels and fPSA/tPSA ratios. Methods: Serum concentrations of total and free as well as JPSA/tPSA were determined in 20 men with histologi-cally confirmed liver cirrhosis, 15 men with chronic hepa-titis and 20 healthy men. Results: The serum levels of total PSA in liver cirrhosis as well as in chronic hepatitis were significantly lower than those observed in control. Free PSA remained unchanged. Conclusions: Our study suggests that despite severe liver dysfunction the tPSA, fPSA as well as the ratio of fPSA/ tPSA were not elevated as it was hypothesized that liver impairment might affect the PSA levels, as liver is a site for PSA metabolism.

Source: DOAJ

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Keywords

20 healthy men
 
chronic hepa-titis
 
chronic hepatitis
 
fPSA
 
fPSA/ tPSA
 
fPSA/tPSA ratios
 
Free PSA
 
JPSA
 
JPSA/tPSA
 
liver cirrhosis
 
liver impairment
 
PSA levels
 
PSA metabolism
 
Serum concentrations
 
serum free prostate specific antigen
 
serum levels
 
severe liver dysfunction
 
total prostate specific antigen
 
total PSA
 
tPSA