Evaluation of the phytochemicals and antidiabetic activity of Ficus bengalensis

International Journal of Diabetes in Developing Countries (Impact Factor: 0.37). 04/2007; 27(2). DOI: 10.4103/0973-3930.37036
Source: DOAJ

ABSTRACT Ficus bengalensis Linn, commonly known as the banyan tree, belongs to the Moraceae family. Its bark is used for the treatment of diabetes. In the present study, the ethanolic extracts of the different aerial parts of Ficus bengalensis Linn were comparatively evaluated for their blood glucose lowering activity. Histopathology of the treated groups was carried out to evaluate the betacytotropic activity of various parts of Ficus bengalensis. The ethanolic extract of the fruit, at a dosage of 120 mg/kg body weight, was found to exert a more pronounced antidiabetic activity than the ethanolic extract of the root or bark. The experiment also confirmed the antidiabetic activity of the standard drug glibenclamide.

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Available from: Shruti Shukla, Sep 28, 2015
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    • "The viscous dark brown mass is than dried in air as dried powered extract. (Sgrawat, al. 2007, Edwin E. 2008). The percentage yield of ethanol extracts of stem barks of FB/DL, FB/GJ and FB/UA was found to be 6.6 %, 9.56 % and 7.0 % respectively. "
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    • "Pharmacologically various extracts of Ficus benghalensis has shown analgesic and antiinflammatory (Thakare V N et al., 2010) 7 , anti-arthritic (Bhardwaj L K et al., 2010) 8 antioxidants (Shukla R et al., 2004) 9 , antidiabetic (Sharma S et al., 2007) 10 , immunomodulatory (Gabhe S Y et al., 2006) 11 and antimicrobial (Gayathri M et al., 2009) 12 activity in experimental animals. "
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    ABSTRACT: ABSTRACT The present laboratory study was carried out to investigate the anthelmintic properties of Ficus benghalensis Linn leaves extracts against Indian earthworms Pheretima posthuma. Alcoholic extract and aqueous extract of leaves were used as test solutions. Albendazole was included as standard drug and normal saline as control. Observations were made for the time taken to paralyze and death of the earthworm. Three concentrations 25mg/ml, 50mg/ml, 100mg/ml of each extract and standard drug at the concentration of 25mg/ml were studied. The results of study indicated that Ficus benghalensis Linn leaves extracts exhibited anthelmintic activity significantly in a dose dependent manner when compared with standard group. For the aqueous extract group the time of paralysis and death time was 3.92 minute and 13.72 minute, while alcoholic extract group showed shortest time of paralysis (P) at 2.12 minute and death (D) at 7.34 minute of earthworms at higher concentration 100mg/ml as compared to standard Albendazole (25mg/ml) paralysis 2.36 minute and death at 6.42 minute respectively. Alcoholic extract showed more pronounced effect than aqueous extract. Whereas the control group worms were observed for full day and night and there was no paralysis or death was found during that period. Keywords: Anthelmintic activity, Albendazole, Ficus benghalensis Linn, Pheretima posthuma
    Asian Journal of Pharmaceutical and Clinical Research 08/2012; Vol 5,(Issue 4,):118-120. · 0.51 Impact Factor
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    ABSTRACT: To evaluate the antidiabetic effects of various fractions of Ipomoia digitata on alloxan induced diabetic in rats. Root powder of the plant was extracted successively with alcohol and water; later the extracts were subjected for phytochemical screening to identify phytoconstituents. LD 50 studies for both the extracts were conducted up to the dose level of 2 g/kg by following "Up and Down method of OECD Guidelines No. 425, 1/5, 1/10 and 1/20 th doses from the maximum LD 50 dose tested were selected for the present study. Anti-diabetic activity was studied in rats by using Low dose 100 mg/kg, medium dose 200 mg/kg, high dose 400 mg/kg of both the extracts. Anti-diabetic activity was studied against alloxan induced diabetes using Glibenclamide 10mg/kg body weight as a standard reference. Biochemical parameters (GLU, CHO, and TRG) were assessed in control/toxicant/standard and extract treated animals in the above mentioned models. During LD 50 studies for both the extracts no mortality was observed in any animals up to the maximum dose level of 2000 mg/kg indicated their practically nontoxic nature. In Glibenclamide, AERID and AQERID treated groups when compared to alloxan toxicant groups the serum GLU, CHO, TRG levels were markedly decreased. These results demonstrate the antidiabetic potential of fractions of Ipomoia digitata and suggest that the plant may have therapeutic value in diabetes and related complications. INTRODUCTION Diabetes mellitus is a syndrome of impaired carbohydrate, fat and protein metabolism caused by either lack of insulin secretion or decreased sensitivity of the tissues to insulin and requires lifelong treatment 1 . The concomitant usage of synthetic drugs in some individuals may cause drug interactions when used to treat many types of ailments, e.g. sulfonamides inhibit metabolism or excretion of anti-diabetic drugs sulfonylureas thereby producing hypoglycemia, while rifampicin increases their metabolism to reduce their hypoglycemic effect. Hence, synthetic drug interactions when considered into account there is a trend now to look for plants and herbal preparations to be used medicinally. In this present work, our intention is to verify the therapeutic usefulness of locally available plants. Literature _____________________________ *Address for correspondence: E-mail: survey revealed that the plant I.digitata was used as ethnic or folklore is given in diabetes apart from other medicinal uses. In ayurveda, i.e. Indian system of medicine, many plant drugs have been reported for their anti-diabetic activity. Some of them are Allium sativum, Allium cepa, gymnema sylvestre, Azadirachta indica, Ocimum sanctum, Momordica charantia, Syzygium cumini and Eugenia jambolana.
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