Evaluation of the phytochemicals and antidiabetic activity of Ficus bengalensis

International Journal of Diabetes in Developing Countries 01/2007; DOI: 10.4103/0973-3930.37036
Source: DOAJ

ABSTRACT Ficus bengalensis Linn, commonly known as the banyan tree, belongs to the Moraceae family. Its bark is used for the treatment of diabetes. In the present study, the ethanolic extracts of the different aerial parts of Ficus bengalensis Linn were comparatively evaluated for their blood glucose lowering activity. Histopathology of the treated groups was carried out to evaluate the betacytotropic activity of various parts of Ficus bengalensis. The ethanolic extract of the fruit, at a dosage of 120 mg/kg body weight, was found to exert a more pronounced antidiabetic activity than the ethanolic extract of the root or bark. The experiment also confirmed the antidiabetic activity of the standard drug glibenclamide.

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    ABSTRACT: ABSTRACT The present laboratory study was carried out to investigate the anthelmintic properties of Ficus benghalensis Linn leaves extracts against Indian earthworms Pheretima posthuma. Alcoholic extract and aqueous extract of leaves were used as test solutions. Albendazole was included as standard drug and normal saline as control. Observations were made for the time taken to paralyze and death of the earthworm. Three concentrations 25mg/ml, 50mg/ml, 100mg/ml of each extract and standard drug at the concentration of 25mg/ml were studied. The results of study indicated that Ficus benghalensis Linn leaves extracts exhibited anthelmintic activity significantly in a dose dependent manner when compared with standard group. For the aqueous extract group the time of paralysis and death time was 3.92 minute and 13.72 minute, while alcoholic extract group showed shortest time of paralysis (P) at 2.12 minute and death (D) at 7.34 minute of earthworms at higher concentration 100mg/ml as compared to standard Albendazole (25mg/ml) paralysis 2.36 minute and death at 6.42 minute respectively. Alcoholic extract showed more pronounced effect than aqueous extract. Whereas the control group worms were observed for full day and night and there was no paralysis or death was found during that period. Keywords: Anthelmintic activity, Albendazole, Ficus benghalensis Linn, Pheretima posthuma
    Asian Journal of Pharmaceutical and Clinical Research 08/2012; Vol 5,(Issue 4,):118-120. · 0.51 Impact Factor
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    ABSTRACT: To evaluate the antidiabetic potential of methanolic extract of Albizia odoratissima Benth. bark in alloxan induced diabetic mice. Group-I (normal control) mice received only basal diet without any treatment. In Group- II (Diabetic control) mice, diabetes was induced by alloxan (150 mg/kg i.p.) and received only Tween 80, 5% v/v in normal saline. Group- III and Group- IV mice received metformin (10mg/kg) and gliclazide (10 mg/kg) as standard drugs. Group- V and VI mice received methanolic bark extract of Albizia odoratissimaat doses of 250 and 500 mg/kg body weight p.o., respectively. The results of the study indicates that Albizia odoratissima bark extract significantly (P<0.01) reduced the blood sugar level. The bark extract also significantly reduced the levels of serum cholesterol, triglycerides, serum glutamic-oxaloacetic transaminase, serum glutamic-pyruvic transaminase, alkaline phosphatase and decreases level of total proteins in alloxan induced diabetic mice. Methanolic extract of Albizia odoratissima has protective effects on the protection of vital tissues (pancreas, kidney, liver, heart and spleen), thereby reducing the causation of diabetes in experimental animals.
    Asian Pacific Journal of Tropical Medicine 11/2011; 4(11):900-3. · 0.50 Impact Factor

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