Amyloid-β Related Memory Decline is not Associated with Subjective or Informant Rated Cognitive Impairment in Healthy Adults.

Journal of Alzheimer's disease: JAD (Impact Factor: 4.15). 08/2014; 43(2). DOI: 10.3233/JAD-140678
Source: PubMed


Background: The detection of early Alzheimer's disease (AD) can rely on subjective and informant reports of cognitive impairment. However, relationships between subjective cognitive impairment, objectively measured cognitive function, and amyloid-β (Aβ) biomarkers remain unclear. Objective: To determine the extent to which impairment or decline in subjective and informant rated cognitive impairment was associated with memory in healthy older adults with high Aβ. Methods: Healthy older adults (n = 289) enrolled in the Australian Imaging, Biomarkers and Lifestyle (AIBL) study were studied at baseline. Pittsburgh Compound B was used to determine Aβ status at baseline. At baseline and 18 months assessments, subjective memory impairment was assessed using the Memory Complaint Questionnaire and the Short Form of the Informant Questionnaire on Cognitive Decline in the Elderly. Cognition was measured using the Cogstate Brief Battery. Results: At baseline, there were no differences between low and high Aβ groups in subjective or informant-rated cognitive impairment, depressive and anxiety symptoms, or cognitive function. Longitudinal analyses showed moderate decline in learning and working memory over the 18 months in the high Aβ group. However there was no change over time in subjective or informant-rated cognitive impairment, depressive and anxiety symptoms, or cognition in either Aβ group. Conclusions: Although healthy older adults with high Aβ levels show decline in learning and working memory over 18 months, subjective or informant ratings of cognitive impairment do not change over the same period suggesting subjective cognitive impairment may have limited utility for the very early identification of AD.

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Available from: Yen Ying Lim, Sep 25, 2014
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    • "A multiple regression analysis showed that depressive symptoms were more related to SMI than anxiety ( = 0.41 and = 0.16, respectively). This finding is consistent with previous cross-sectional studies postulating that SMI are more strongly associated with severity of depressive and anxiety symptomatology than performance on neuropsychological tests [3] [4] [5] [6] [7], even when using a test sensitive to preclinical AD such as the FNAME [23]. The lack of relationship between subjective and objective memory impairment does not rule out that patients with SMI have an increased risk of developing cognitive impairment and dementia than subjects without SMI [2, 16–18]. "
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