Risk of suicidal behavior with antidepressants in bipolar and unipolar disorders.
The Journal of Clinical Psychiatry (Impact Factor: 5.14). 07/2014; 75(7):720-727. DOI: 10.4088/JCP.13m08744
ABSTRACT To examine the risk of suicidal behavior (suicide attempts and deaths) associated with antidepressants in participants with bipolar I, bipolar II, and unipolar major depressive disorders.
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ABSTRACT: Bipolar disorder is associated with high mortality, and people with this disorder on average may die 10-20 years earlier than the general population. This excess and premature mortality continues to occur despite a large and expanding selection of treatment options dating back to lithium and now including anticonvulsants, antipsychotics, and evidence-based psychotherapies. This review summarizes recent findings on mortality in bipolar disorder, with an emphasis on the role of suicide (accounting for about 15 % of deaths in this population) and cardiovascular disease (accounting for about 35-40 % of deaths). Recent care models and treatments incorporating active outreach, integrated mental and physical health care, and an emphasis on patient self-management have shown promise in reducing excess mortality in this population.Current Psychiatry Reports 11/2014; 16(11):499. DOI:10.1007/s11920-014-0499-z · 3.05 Impact Factor
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