Article

The antimicrobial susceptibility of Stenotrophomonas maltophilia isolates using three different methods and their genetic relatedness

BMC Microbiology 01/2005;
Source: DOAJ

ABSTRACT Abstract

Background

Stenotrophomonas maltophilia is inherently resistant to many antimicrobials. So far, antimicrobial susceptibility tests for S. maltophilia have not been fully standardized. The purpose of the study was to compare the susceptibility of S. maltophilia isolates against seven different antimicrobials using three different methods and to investigate their genetic relatedness.

Results

Although trimethoprim/sulfamethoxazole (SXT) and ciprofloxacin have the lowest MIC values, SXT (98.1%) and ticarcillin/clavulanate (TLc) (73.1%) were found to be the most effective antimicrobials by agar dilution method, which was in accordance with the breakpoints established by NCCLS. Disc diffusion and E-test was in agreement with agar dilution method for SXT. When the isolation dates, clinics, antibiotyping, and AP-PCR data were investigated, two small outbreaks consisting of five and three cases were determined.

Conclusion

By using the NCCLS criteria, disc diffusion and E-test were unreliable alternative methods for S. maltophilia , except for SXT. However, the significance of these data should be confirmed by further experimental and clinical studies.

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Keywords

agar dilution method
 
antimicrobial susceptibility tests
 
antimicrobials
 
AP-PCR data
 
cases
 
ciprofloxacin
 
clinical studies
 
clinics
 
different antimicrobials
 
different methods
 
Disc diffusion
 
effective antimicrobials
 
genetic relatedness
 
isolation dates
 
lowest MIC values
 
NCCLS
 
NCCLS criteria
 
S. maltophilia
 
SXT
 
ticarcillin/clavulanate