Article

Effects of calcium supplement therapy in women with premenstrual syndrome.

ValiAsr Reproductive Health Research Center, Tehran University of Medical Sciences, Tehran, Iran.
Taiwanese journal of obstetrics & gynecology 07/2009; 48(2):124-9. DOI:10.1016/S1028-4559(09)60271-0 pp.124-9
Source: PubMed

ABSTRACT Scientific evidence suggests that cyclic fluctuations in a variety of nutrients, especially calcium, may help to explain some features of premenstrual syndrome (PMS). We determined the efficacy of calcium supplementation in women suffering from PMS.
A double-blind clinical trial was designed to evaluate the effect of calcium supplement therapy on PMS symptoms. The study groups were selected from young female college students, based on PMS criteria. The subjects were divided in two groups; one group received placebo and the other received 500 mg of calcium carbonate twice daily for 3 months. The severity and intensity of symptoms, including early fatigability, changes in appetite, and depression, were evaluated using a standard questionnaire. Symptoms were compared before and after treatment.
The mean age was 21.4 +/- 3.6 years. Early tiredness, appetite changes, and depressive symptoms were significantly improved in the group receiving calcium treatment compared with the placebo group.
Our results showed that calcium supplements reduced early fatigability, changes in appetite, and depression in women with PMS.

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Keywords

appetite changes
 
calcium carbonate
 
calcium supplement therapy
 
calcium supplementation
 
calcium supplements
 
calcium treatment
 
cyclic fluctuations
 
depressive symptoms
 
double-blind clinical trial
 
mean age
 
placebo group
 
PMS criteria
 
PMS symptoms
 
premenstrual syndrome
 
received 500 mg
 
Scientific evidence
 
standard questionnaire
 
study groups
 
Symptoms
 
young female college students
 

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