Article

NB4 cells treated with all-trans retinoic acid generate toxic reactive oxygen species that cause endothelial hyperpermeability.

Department of Hematology and Oncology, Kyoto University Hospital, Kyoto 606-8507, Japan.
Leukemia research (impact factor: 2.36). 07/2009; 34(3):373-8. DOI:10.1016/j.leukres.2009.05.022 pp.373-8
Source: PubMed

ABSTRACT Retinoic acid syndrome (RAS) is a serious complication during induction therapy with all-trans retinoic acid (RA) in patients with acute promyelocytic leukemia. In this study, we examined whether reactive oxygen species (ROS) were involved in capillary leak phenomenon in RAS, using NB4 cells. When cells were stimulated by phorbol 12-myristate 13-acetate, RA-treated cells with matured myeloperoxidase produced toxic ROS, such as singlet oxygen, hypochlorous acid and hydroxyl radical, and brought about endothelial hyperpermeability. Leukemic cells from a patient also produced toxic ROS. These findings indicated that toxic ROS contribute to the development of capillary leak phenomenon in RAS.

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Keywords

acute promyelocytic leukemia
 
all-trans retinoic acid
 
capillary leak phenomenon
 
endothelial hyperpermeability
 
hydroxyl radical
 
hypochlorous acid
 
induction therapy
 
Leukemic cells
 
NB4 cells
 
phorbol 12-myristate 13-acetate
 
RA
 
RA-treated cells
 
RAS
 
reactive oxygen species
 
Retinoic acid syndrome
 
toxic ROS
 

Takashi Miyoshi