Distinct Cerebellar Contributions to Intrinsic Connectivity Networks
Service de NeuroImagerie, Hôpital des Quinze-Vingts, Université Pierre et Marie Curie Paris 6, 75012 Paris, France.The Journal of Neuroscience : The Official Journal of the Society for Neuroscience (Impact Factor: 6.34). 08/2009; 29(26):8586-94. DOI: 10.1523/JNEUROSCI.1868-09.2009
Convergent data from various scientific approaches strongly implicate cerebellar systems in nonmotor functions. The functional anatomy of these systems has been pieced together from disparate sources, such as animal studies, lesion studies in humans, and structural and functional imaging studies in humans. To better define this distinct functional anatomy, in the current study we delineate the role of the cerebellum in several nonmotor systems simultaneously and in the same subjects using resting state functional connectivity MRI. Independent component analysis was applied to resting state data from two independent datasets to identify common cerebellar contributions to several previously identified intrinsic connectivity networks (ICNs) involved in executive control, episodic memory/self-reflection, salience detection, and sensorimotor function. We found distinct cerebellar contributions to each of these ICNs. The neocerebellum participates in (1) the right and left executive control networks (especially crus I and II), (2) the salience network (lobule VI), and (3) the default-mode network (lobule IX). Little to no overlap was detected between these cerebellar regions and the sensorimotor cerebellum (lobules V-VI). Clusters were also located in pontine and dentate nuclei, prominent points of convergence for cerebellar input and output, respectively. The results suggest that the most phylogenetically recent part of the cerebellum, particularly crus I and II, make contributions to parallel cortico-cerebellar loops involved in executive control, salience detection, and episodic memory/self-reflection. The largest portions of the neocerebellum take part in the executive control network implicated in higher cognitive functions such as working memory.
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- "Recent work analyzing subcortical contributions to the ICNs has paid little attention to cerebellar connectivity. Those studies that have assessed cerebellar connectivity with the ICNs have been promising, demonstrating cerebellar contributions to all functional networks (Habas et al. 2009). Importantly, these studies have shown that regions of the cerebellum contribute distinctly to individual networks, with some regions such as cerebellar Crus I, Crus II and lobule VI contributing specifically to cortical networks such as the executive control and salience networks (Habas et al. 2009; O'Reilly et al. 2010; Bucker et al. 2011; Bernard et al. 2012). "
ABSTRACT: This study characterized cerebellar connectivity with executive intrinsic functional connectivity networks. Using seed regions at the right and left dorsolateral prefrontal cortices (dlPFC) and right orbital frontoinsula, we measured resting-state brain connectivity in healthy college-aged participants. Based on the previous research demonstrating a relationship between the cerebellum and self-report measures of behavioral inhibition, we assessed individual differences in connectivity between groups. Overall, intrinsic activity in cerebellar lobule VIII was significantly correlated with the executive network and cerebellar Crus I with the salience network. Between-group comparisons indicated stronger cerebellar connectivity with the executive network in behaviorally inhibited individuals. Intrinsic activity in Crus I, a region previously implicated in non-motor cerebellar functions, significantly correlated with intrinsic activity in the right dlPFC seed region. These findings support a growing number of studies demonstrating cerebellar influence on higher cognitive processes, extending this relationship to individual differences in anxiety vulnerability.Brain Structure and Function 08/2015; DOI:10.1007/s00429-015-1088-6 · 5.62 Impact Factor
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