Article

Synthesis and biological evaluation of ether bridged bicyclic iminosugar derivatives.

Biotechnology Center in Southern Taiwan, Academia Sinica, 2F., No. 22, Lane 31, Sec. 1, Huandong Rd., Sinshih Township, Tainan County 744, Taiwan.
Carbohydrate research (Impact Factor: 2.03). 07/2009; 344(13):1639-45. DOI: 10.1016/j.carres.2009.05.029
Source: PubMed

ABSTRACT Bicyclic iminosugar derivatives with an ether bridge bearing different substituents on C-2 and the nitrogen atom have been synthesized from a C-glycoside bearing an isopropylidene acetal. The activities of these compounds were investigated against several glycosidase enzymes and showed moderate inhibition and activation.

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