Vascular risk factors and their association to serum androgen levels in a population-based cohort of 75-year-old men over 5 years: Results of the VITA study

Department of Urology and Andrology, Danube Hospital, SMZ-Ost, Langobardenstrasse 122, 1220 Vienna, Austria.
World Journal of Urology (Impact Factor: 2.67). 07/2009; 28(2):209-14. DOI: 10.1007/s00345-009-0440-y
Source: PubMed


In contrast to the high prevalence of late onset hypogonadism, little is known regarding correlates for low androgen levels in aging men.
We investigated participants of the Vienna Transdanube Aging study and assessed the relationship between vascular risk factors and hormonal status over 5 years.
A total of 247 men with a mean age of 75.8 years were analyzed. Despite a tendency for lower testosterone levels in men with vascular risk factors and vascular diseases, none of these associations reached statistical significance. Men with low DHEA-S levels had a lower risk of hypercholesterinemia (-55.2%; P = 0.01) yet an increased prevalence of diabetes (+95.7%; P = 0.02) and coronary heart disease (+47.6%; P = 0.05). Testosterone and DHEA-S remained stable over 5 years of follow-up.
While reduced levels of total testosterone did not show an association to vascular disease, low DHEA-S was linked to hypercholesterinemia, diabetes, and coronary heart disease.

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