Adenomatoid tumors of the female and male genital tracts: a clinicopathological and immunohistochemical study of 44 cases
ABSTRACT Adenomatoid tumors of the female and male genital tracts are well characterized as mesothelial in origin, but a detailed histological and immunohistochemical analysis comparing both traditional and newer mesothelial markers across gender and site has not been formally conducted. A variety of morphologic features previously described as characteristic of adenomatoid tumors were evaluated in 44 adenomatoid tumors from the male and female genital tracts. Immunohistochemical analysis with pankeratin (AE1/CAM5.2), WT-1, calretinin, CK5/6, D2-40, and caldesmon was also performed. The extent and intensity of staining were scored semiquantitatively on one representative section per case and mean value for each parameter was calculated. All (n=44) the adenomatoid tumors from both the female and male genital tracts demonstrated a distinctive thread-like bridging strand pattern. Lymphoid aggregates were seen in all 12 adenomatoid tumors of male patients, but in only 4 of 32 (13%) tumors in female patients (P<0.0001). The remaining morphologic features were variably present with no clear sex predilection. Pankeratin, calretinin, and D2-40 reactivity were identified in all female (n=32) and male (n=12) genital tract adenomatoid tumors. Adenomatoid tumors expressed WT-1 in 11/12 (92%) male patients and in 31/32 (97%) female patients. In male patients, reactivity for CK5/6 and caldesmon was found in 1/12 (8%) and 0/12 (0%) adenomatoid tumors (respectively), whereas reactivity in female patients was found in 5/32 (16%) and 1/32 (3%); respectively. Female tumors differ from their male counterparts by the frequent absence of lymphoid aggregates and the presence of a circumscribed margin when occurring in the fallopian tube. Of the putative mesothelial markers evaluated, calretinin, D2-40, and WT-1 show a similar immunoprofile and have a higher sensitivity than CK5/6 and caldesmon in genital tract adenomatoid tumors. However, the presence of additional, often strong expression of WT-1 in normal tissues of the female genital tract limits the utility of WT-1 in this setting.
SourceAvailable from: Srikanth Umakanthan[Show abstract] [Hide abstract]
ABSTRACT: Adenomatoid tumoris the most common benign tumor of the fallopian tube. We report a case of 27 year old woman who was operated for right lower quadrant pain and vaginal discharge.The right tubal segment was occluded at the fimbriated end, with a well circumscribed nodule. Microscopy showed closely packed tubulo–glandular and duct like spaces lined by cuboidal to flattened tumor cells, confirming the diagnosis of adenomatoid tumor. INTRODUCTION A 27 year old Para1 Live1 female presented with pain in the right lower quadrant and vaginal discharge. Tubectomy was performed and the specimen was sent for histopathology examination. On gross examination the right tubal segment with an occluded fimbriated end revealed a well circumscribed nodule measuring two cms in diameter lying beneath the serosa. Cut surface was smooth, gray white and homogenous. (Fig 1A,B). Microscopy of the tubal lesion showed a tumorcomposed of closely packed tubulo–glandular and duct like spaces that are elongated to cysticallydilated with oval vacuoles around the lumen of the fallopian tube. These spaces are lined by tumor cells which are cuboidal to flattened with bland nuclei and mitosis is absent. The stroma is sparsely cellular (Fig 2A,B). A diagnosis of adenomatoidtumorof the fallopian tube was made.
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ABSTRACT: Adenomatoid tumoris the most common benign tumor of the fallopian tube. We report a case of 27 year old woman who was operated for right lower quadrant pain and vaginal discharge.The right tubal segment was occluded at the fimbriated end, with a well circumscribed nodule. Microscopy showed closely packed tubulo–glandular and duct like spaces lined by cuboidal to flattened tumor cells, confirming the diagnosis of adenomatoid tumor.
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ABSTRACT: Mesothelin, a mesothelial marker, has been found expressed in and as a potential treatment target of cholangioacarcinoma (CC). It is possible that CC may be derived from the cells sharing mesothelial markers. However, the expression of other mesothelial markers in CC is largely unknown.04/2014; 3:12. DOI:10.1186/2162-3619-3-12