The Influence of IgE-Enhancing and IgE-Suppressive T Cells Changes with Exposure to Inhaled Ovalbumin

Integrated Department of Immunology, National Jewish Health, Denver, CO 80206, USA.
The Journal of Immunology (Impact Factor: 4.92). 07/2009; 183(2):849-55. DOI: 10.4049/jimmunol.0804104
Source: PubMed


It has been reported that the IgE response to allergens is influenced by gammadelta T cells. Intrigued by a study showing that airway challenge of mice with OVA induces in the spleen the development of gammadelta T cells that suppress the primary IgE response to i.p.-injected OVA-alum, we investigated the gammadelta T cells involved. We found that the induced IgE suppressors are contained within the Vgamma4(+) subset of gammadelta T cells of the spleen, that they express Vdelta5 and CD8, and that they depend on IFN-gamma for their function. However, we also found that normal nonchallenged mice harbor IgE-enhancing gammadelta T cells, which are contained within the larger Vgamma1(+) subset of the spleen. In cell transfer experiments, airway challenge of the donors was required to induce the IgE suppressors among the Vgamma4(+) cells. Moreover, this challenge simultaneously turned off the IgE enhancers among the Vgamma1(+) cells. Thus, airway allergen challenge differentially affects two distinct subsets of gammadelta T cells with nonoverlapping functional potentials, and the outcome is IgE suppression.

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    • "These regulatory functions are speculated to be mediated by different γδ T cells. For example, innate Vγ1+ T cells, including Vγ1Vδ5+ subsets, can enhance IgE responses, whereas acquired Vγ4+ T cells repress the αβ T cell-dependent antigen-specific IgE responses [29]. Collectively, these findings suggest that γδ T cells have complex immunomodulatory functions upon B lymphocytes similar to that on αβ T cells and this phenomenon may be related to the subsets of γδ T cells. "
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