Article

Pharmacosomes: The lipid-based new drug delivery system

HNB Garhwal University Srinagar, Department of Pharmaceutical Sciences, Garhwal-246174, India.
Expert Opinion on Drug Delivery (Impact Factor: 4.12). 07/2009; 6(6):599-612. DOI: 10.1517/17425240902967607
Source: PubMed

ABSTRACT Lipid-based drug delivery systems have been investigated in various studies and shown their potential in controlled and targeted drug delivery. Pharmacosomes are amphiphilic phospholipid complexes of drugs bearing active hydrogen that bind to phospholipids. Pharmacosomes impart better biopharmaceutical properties to the drug, resulting in improved bioavailability. Pharmacosomes have been prepared for various non-steroidal anti-inflammatory drugs, proteins, cardiovascular and antineoplastic drugs. Developing the pharmacosomes of the drugs has been found to improve the absorption and minimize the gastrointestinal toxicity. This article reviews the potential of pharmacosomes as a controlled and targeted drug delivery system and highlights the methods of preparation and characterization.

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Available from: Ajay Semalty, Aug 02, 2015
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    • "For many applications, delivery systems are needed that can be incorporated into high-moisture food matrices, such as those in beverages , yogurts, dressings, sauces, creams, soups, dips, and desserts. A variety of different emulsion-based delivery systems have been developed to encapsulate lipophilic bioactive agents, including emulsions, nanoemulsions, multiple emulsions, multilayer emulsions, filled hydrogel particles, and solid lipid nanoparticles (Gershkovich et al., 2008; Han et al., 2009; Lee et al., 2008; McClements, 2010; McClements et al., 2008; Nordly et al., 2009; Semalty et al., 2009). Each of these delivery systems has their own advantages and disadvantages in terms of cost, ease of preparation, in-product stability, product compatibility, ingredient utilization , and functional performance (McClements, 2014). "
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    • "Several studies have described the beneficial effects of phospholipids in tumor and metastasis inhibition (Küllenberg et al., 2012). Many investigations have shown that complexation of drug with phospholipids improves both permeation and oral absorption (Singh et al., 2014; Tan et al., 2012; Gupta and Dixit, 2011; Yu et al., 2010; Semalty et al., 2009a; Maiti et al., 2007). "
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    ABSTRACT: In th e p res en t study, ta m oxif en -p h os p h ol ip id co m p l ex ( TM X-P L C) wa s de vel o p ed an d e va lu ate d for its impact on s o lu bi li ty an d bi o avai la b il it y of ta m oxif en . TM X-P L C wa s p rep a red by s o lven t evap o rat io n m e th od and c ha racte r iz ed . FTIR reve al e d th e di sa p p ea ran ce of th e ch ara cte r is ti c pe ak s of TMX in th e c om p lex, wh i ch ca n be du e to wea ke n in g , rem oval or s h ie l di ng by th e phospholi pid m o le c ul e. Th i s p h en om e n on co u ld be du e to pa cki n g of TM X in th e hyd rop ho bi c cavi ty of p h os p h ol ip id an d be in g hel d by van de r Wa a l s fo rc es an d hyd ro ph o bi c in tera ct i on s . Th i s o bs er vati on wa s co n fi rme d by DSC and PX RD . TM X-P L C exh ib ite d in cr ea s ed so lu bi l it y, di s so l ut io n rate wi th de cre as ed di st r i bu ti o n co ef fi ci en t indicating it s in cr ea s ed hyd rop h il ic i ty. Ora l bi oavai l ab i li ty of TM X an d TMX-P LC were evalu ate d in Sp rag ue -D awl ey (SD) rat s . TM X- PL C exh i bi ted co ns i de rab l e en h an ce m e nt in th e bi oavai l ab i li ty wi th an i n cre as e in C max (0.85 vs. 0.40 m g/mL), t 1/2 (22.47 vs . 13.93 h), and AU C 0 –1(15.29 vs. 8.62 m g h/mL) with 212.25% relative bioavailability. This enhancement can be attributed to the improvement of the aqueous solubility of the complex and a probable decrease in its extent of intestinal and hepatic metabolism. Thus, phospholipid complexation holds a promising potential for increasing oral bioavailability of TMX.
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    • "Several studies have described the beneficial effects of phospholipids in tumor and metastasis inhibition (Küllenberg et al., 2012). Many investigations have shown that complexation of drug with phospholipids improves both permeation and oral absorption (Singh et al., 2014; Tan et al., 2012; Gupta and Dixit, 2011; Yu et al., 2010; Semalty et al., 2009a; Maiti et al., 2007). "
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