Effect of Coffee and Green Tea Consumption on the Risk of Liver Cancer: Cohort Analysis by Hepatitis Virus Infection Status

Epidemiology and Prevention Division, Research Center for Cancer Prevention and Screening, National Cancer Center, Tokyo, Japan.
Cancer Epidemiology Biomarkers & Prevention (Impact Factor: 4.13). 06/2009; 18(6):1746-53. DOI: 10.1158/1055-9965.EPI-08-0923
Source: PubMed


In spite of their anticarcinogenic potential, the effect of coffee and green tea consumption on the risk of liver cancer has not been clarified prospectively in consideration of hepatitis C (HCV) and B virus (HBV) infection. We examined whether coffee and green tea consumption was associated with a reduced risk of liver cancer by hepatitis virus infection status in the Japan Public Health Center-Based Prospective Study Cohort II. A total of 18,815 subjects ages 40 to 69 years participating in a questionnaire and health checkup survey in 1993 to 1994 were followed for the incidence of liver cancer through 2006. A total of 110 cases of liver cancer were newly documented. Hazard ratios for coffee and green tea consumption categories were calculated with a Cox proportional hazards model. Compared with almost never drinkers, increased coffee consumption was associated with a reduced risk of liver cancer in all subjects (hazard ratio for <1, 1-2, and >or=3 cups/d; P(trend) = 0.67, 0.49, 0.54, and 0.025). A similar risk tendency was observed in those with either or both HCV and HBV infection. In contrast, no association was observed between green tea consumption and the risk of liver cancer in all subjects. Our results suggest that coffee consumption may reduce the risk of liver cancer regardless of HCV and HBV infection status, whereas green tea may not reduce this risk

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    • "Previous studies support our results [3e5,17]. Contrary to these other major causes of death, green tea showed no association with cancer mortality; most of other studies also found null associations between green tea and all-cancer mortality [3] [4] [18], although the site-specific incidence of cancer showed varying associations with green tea [13] [16] [19] [20] in humans. "
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    ABSTRACT: Background and Purpose: We examined the association between green tea consumption and mortality due to all causes, cancer, heart disease, cerebrovascular disease, respiratory disease, injuries and other causes of death in a large-scale population-based cohort study in Japan. Methods We studied 90,914 Japanese (aged between 40 and 69 years) recruited between 1990 and 1994. After 18.7 years of follow-up, 12,874 deaths were reported. The association between green tea consumption and risk of all causes and major causes of mortality was assessed using the Cox proportional hazards regression model with adjustment for potential confounders. Results Hazard ratios for all-cause mortality among men who consumed green tea compared with those who drank less than 1 cup per day were 0.96 (0.89 to 1.03) for 1 to 2 cups per day, 0.88 (0.82 to 0.95) for 3 to 4 cups per day, and 0.87 (0.81 to 0.94) for more than 5 cups per day (p for trend <0.001). Corresponding hazard ratios for women were 0.90 (0.81 to 1.00), 0.87 (0.79 to 0.96), and 0.83 (0.75 to 0.91) (p for trend <0.001). Green tea was inversely associated with mortality from heart disease in both men and women, and mortality from cerebrovascular disease and respiratory disease in men. No association was found between green tea and total cancer mortality. Conclusion This prospective study suggests that the consumption of green tea may reduce the risk of all-cause mortality and the three leading causes of death in Japan.
    Annals of Epidemiology 03/2015; 25(7). DOI:10.1016/j.annepidem.2015.03.007 · 2.00 Impact Factor
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    • "A flow diagram of study selection is provided as Figure 1. Among the 41 articles, 15 assessed the relationship between tea drinking and the incidence for breast cancer [25,33,41,49,51,54-63], 15 for colorectal cancer [10,11,18,26-29,31,38-41,44,45],[59], 4 for liver cancer [18,27,64,65], 7 for prostate cancer [30,50,53,66-69], and 5 for stomach cancer [27,42,43,52,59]. The 41 articles included had 3,027,702 participants and 49,103 cancer cases. "
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    ABSTRACT: We conducted a dose-response meta-analysis of prospective studies to summarize evidence of the association between tea consumption and the risk of breast, colorectal, liver, prostate, and stomach cancer. We searched PubMed and two other databases. Prospective studies that reported risk ratios (RRs) with 95% confidence intervals (CIs) of cancer risk for >=3 categories of tea consumption were included. We estimated an overall RR with 95% CI for an increase of three cups/day of tea consumption, and, usingrestricted cubic splines, we examined a nonlinear association between tea consumption and cancer risk. Forty-one prospective studies, with a total of 3,027,702 participants and 49,103 cancer cases, were included. From the pooled overall RRs, no inverse association between tea consumption and risk of five major cancers was observed. However, subgroup analysis showed that increase in consumption of three cups of black tea per day was a significant risk factor for breast cancer (RR, 1.18; 95% CI, 1.05-1.32). Ourresults did not show a protective role of tea in five major cancers. Additional large prospective cohort studies are needed to make a convincing case for associations.
    BMC Cancer 03/2014; 14(1):197. DOI:10.1186/1471-2407-14-197 · 3.36 Impact Factor
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    • "There were nine case–control studies [11-19] and seven cohort studies (two of these were nested in a cohort article) [20-25]. Of the selected studies, 11 were conducted in Asia (nine in Japan [14,15,17,18,20-22,24], one in Singapore [25], one in Hong Kong [19]) and five in Europe (one in Finland [23], two in Italy [13,16], one in Greece [11], one in Italy and Greece [12]). Among case–control studies, seven were hospital-based case–control studies [11-16,19], and two were nested case- control studies [17,18]. "
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    ABSTRACT: Background Epidemiologic studies have reported inconsistent results regarding coffee consumption and the risk of liver cancer. We performed a meta-analysis of published case–control and cohort studies to investigate the association between coffee consumption and liver cancer. Methods We searched Medline, EMBASE, ISI Web of Science and the Cochrane library for studies published up to May 2012. We performed a meta-analysis of nine case–control studies and seven cohort studies. Results The summary odds ratio (OR) for high vs no/almost never drinkers was 0.50 (95% confidence interval (CI): 0.42–0.59), with no significant heterogeneity across studies (Q = 16.71; P = 0.337; I2 = 10.2%). The ORs were 0.50 (95% CI: 0.40–0.63) for case–control studies and 0.48 (95% CI: 0.38–0.62) for cohort studies. The OR was 0.38 (95% CI: 0.25–0.56) in males and 0.60 (95% CI: 0.33–1.10) in females. The OR was 0.45 (95% CI: 0.36–0.56) in Asian studies and 0.57 (95% CI: 0.44–0.75) in European studies. The OR was 0.39 (95% CI: 0.28–0.54) with no adjustment for a history of liver disease and 0.54 (95% CI: 0.46–0.66) after adjustment for a history of liver disease. Conclusions The results of this meta-analysis suggested an inverse association between coffee consumption and liver cancer. Because of the small number of studies, further prospective studies are needed.
    BMC Gastroenterology 02/2013; 13(1):34. DOI:10.1186/1471-230X-13-34 · 2.37 Impact Factor
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