Diffuse optical correlation tomography of cerebral blood flow during cortical spreading depression in rat brain.

Optics Express (Impact Factor: 3.53). 03/2006; 14(3):1125-44. DOI: 10.1364/OE.14.001125
Source: PubMed

ABSTRACT Diffuse optical correlation methods were adapted for three-dimensional (3D) tomography of cerebral blood flow (CBF) in small animal models. The image reconstruction was optimized using a noise model for diffuse correlation tomography which enabled better data selection and regularization. The tomographic approach was demonstrated with simulated data and during in-vivo cortical spreading depression (CSD) in rat brain. Three-dimensional images of CBF were obtained through intact skull in tissues(~4mm) deep below the cortex.

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Available from: Joel H Greenberg, Dec 17, 2013
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