Article

Testicular adrenal rest tumours in congenital adrenal hyperplasia.

Department of Paediatric Endocrinology, Radboud University Nijmegen Medical Centre, The Netherlands.
Best practice & research. Clinical endocrinology & metabolism (impact factor: 3.89). 05/2009; 23(2):209-20. DOI:10.1016/j.beem.2008.09.007 pp.209-20
Source: PubMed

ABSTRACT In adult patients with congenital adrenal hyperplasia (CAH) the presence of testicular adrenal rest tumours (TART) is an important cause of gonadal dysfunction and infertility. In the last decade several papers have focused on the origin and pathogenesis of these tumours. In this paper we review the embryological, histological, biochemical and clinical features of TART and discuss the treatment options. Furthermore, we propose a new five-stage classification of TART, based on sonographic, clinical and biochemical parameters, that may lead to a better follow up and treatment of patients with TART.

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Keywords

adult patients
 
biochemical
 
biochemical parameters
 
CAH
 
congenital adrenal hyperplasia
 
gonadal dysfunction
 
last decade
 
new five-stage classification
 
papers
 
pathogenesis
 
testicular adrenal rest tumours
 
treatment options
 

H L Claahsen-van der Grinten