Neuropsychiatric disorders: Shared genetics of bipolar disorder and schizophrenia

Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, 600 N. Wolfe Street, Baltimore, MD 21287, USA.
Nature Reviews Neurology (Impact Factor: 14.1). 07/2009; 5(6):299-300. DOI: 10.1038/nrneurol.2009.71
Source: PubMed

ABSTRACT Bipolar disorder and schizophrenia share common clinical features, and antipsychotic medications can treat both conditions effectively. An assessment of 73,929 people with bipolar disorder and/or schizophrenia from a Swedish registry found evidence that the two disorders also share more than half of their genetic determinants.

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Available from: James B Potash, Feb 13, 2015
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    • "A variety of neurocognitive dysfunctions , in particular sustained attention (Braff, 1993 ; Chan et al. 2006a, b ; Arts et al. 2008), verbal and visual memory (Heaton et al. 2001 ; Chan et al. 2006a ; Hill et al. 2008), working memory (Gold et al. 1997 ; Chan et al. 2006b ; Glahn et al. 2007 ; Arts et al. 2008) and executive functions (Chan et al. 2004 ; Glahn et al. 2007), has been demonstrated in both disorders. Moreover, empirical findings from genetics, electrophysiology and neuroimaging (Shifman et al. 2004 ; Potash & Bienvenu, 2009 ; Ellison-Wright & Bullmore, 2010 ; Ivleva et al. 2010 ; Yu et al. 2010) have also converged to support the concept of unitary psychosis or continuum of psychosis (Crow, 1986 ; Linscott & van Os, 2010). "
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