Article

Does Vitamin D Reduce the Risk of Dementia?

Sunlight, Nutrition, and Health Research Center (SUNARC), P.O. Box 641603, San Francisco, CA 94164-1603, USA.
Journal of Alzheimer's disease: JAD (Impact Factor: 3.61). 06/2009; 17(1):151-9. DOI: 10.3233/JAD-2009-1024
Source: PubMed

ABSTRACT The understanding of the role of vitamin D in maintaining optimal health has advanced sharply in the past two decades. There is mounting evidence for beneficial roles for vitamin D in reducing the risk of bone diseases and fractures, many types of cancer, bacterial and viral infections, autoimmune diseases, and cardiovascular diseases. Recently, several reports have also been published regarding the role of vitamin D in neuroprotection. This article develops the hypothesis that vitamin D can reduce the risk of developing dementia, presenting the evidence from observational and laboratory studies. The observational evidence includes that low serum 25-hydroxyvitamin D [25(OH)D] has been associated with increased risk for cardiovascular diseases, diabetes mellitus, depression, dental caries, osteoporosis, and periodontal disease, all of which are either considered risk factors for dementia or have preceded incidence of dementia. The laboratory evidence includes several findings on the role of vitamin D in neuroprotection and reducing inflammation. Although this evidence is supportive, there do not appear to be observational studies of incidence of dementia with respect to prediagnostic serum 25(OH)D or vitamin D supplementation. Such studies now appear to be warranted.

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Available from: William Burgess Grant, Aug 07, 2015
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    • "Indeed, 1,25(OH) 2 D 3 has been shown in vitro to diminish neuronal damage related to ageing, ischemic brain injury, seizures, and elevated levels of transition metals [49] [83] [84], and to attenuate neuronal cell damage evoked by a plethora of toxic agents [85] [86]. Evidence from observational and laboratory studies supporting the hypothesis that vitamin D can reduce the risk of developing dementia has been reviewed [87]. The observational evidence includes the fact that low serum 25(OH)D levels are associated with increased risk of cardiovascular periodontal diseases, diabetes mellitus, depression, dental caries, and osteoporosis – all of which are either considered risk factors for dementia or have preceded incidence of dementia, while the laboratory evidence includes findings on the role of vitamin D in neuroprotection and inflammation reduction. "
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    Medical Hypotheses 08/2011; 77(5):765-72. DOI:10.1016/j.mehy.2011.07.033 · 1.07 Impact Factor
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    • "One set of evidence is that several Global reduction in mortality rates with vitamin D WB Grant diseases linked to low serum 25(OH)D levels often precede Alzheimer's disease. Such diseases include CVD, diabetes mellitus, depression, dental caries, osteoporosis and periodontal disease (Grant, 2009a). A second is that low vitamin D has been associated with cognitive impairment (Llewellyn et al., 2011), often the first sign that Alzheimer's disease is developing. "
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    • "Dementia ( Buell et al . , 2010 ; Grant , 2009 ) and in particular , Alzhei - mer ' s disease have also been linked with low 25OHD levels ( Evatt et al . , 2008 ) . "
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