Does Vitamin D Reduce the Risk of Dementia?

Sunlight, Nutrition, and Health Research Center (SUNARC), P.O. Box 641603, San Francisco, CA 94164-1603, USA.
Journal of Alzheimer's disease: JAD (Impact Factor: 4.15). 06/2009; 17(1):151-9. DOI: 10.3233/JAD-2009-1024
Source: PubMed

ABSTRACT The understanding of the role of vitamin D in maintaining optimal health has advanced sharply in the past two decades. There is mounting evidence for beneficial roles for vitamin D in reducing the risk of bone diseases and fractures, many types of cancer, bacterial and viral infections, autoimmune diseases, and cardiovascular diseases. Recently, several reports have also been published regarding the role of vitamin D in neuroprotection. This article develops the hypothesis that vitamin D can reduce the risk of developing dementia, presenting the evidence from observational and laboratory studies. The observational evidence includes that low serum 25-hydroxyvitamin D [25(OH)D] has been associated with increased risk for cardiovascular diseases, diabetes mellitus, depression, dental caries, osteoporosis, and periodontal disease, all of which are either considered risk factors for dementia or have preceded incidence of dementia. The laboratory evidence includes several findings on the role of vitamin D in neuroprotection and reducing inflammation. Although this evidence is supportive, there do not appear to be observational studies of incidence of dementia with respect to prediagnostic serum 25(OH)D or vitamin D supplementation. Such studies now appear to be warranted.

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Available from: William Burgess Grant, Sep 28, 2015
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    • "Indeed, 1,25(OH) 2 D 3 has been shown in vitro to diminish neuronal damage related to ageing, ischemic brain injury, seizures, and elevated levels of transition metals [49] [83] [84], and to attenuate neuronal cell damage evoked by a plethora of toxic agents [85] [86]. Evidence from observational and laboratory studies supporting the hypothesis that vitamin D can reduce the risk of developing dementia has been reviewed [87]. The observational evidence includes the fact that low serum 25(OH)D levels are associated with increased risk of cardiovascular periodontal diseases, diabetes mellitus, depression, dental caries, and osteoporosis – all of which are either considered risk factors for dementia or have preceded incidence of dementia, while the laboratory evidence includes findings on the role of vitamin D in neuroprotection and inflammation reduction. "
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    ABSTRACT: The hypothesis is formulated and presented that resveratrol and vitamin D have important mutual processes, interactions and induced effects that if not taken into account could seriously jeopardize the interpretation of their current and future preclinical, epidemiological and clinical studies. In support of this hypothesis, evidence is presented that resveratrol and vitamin D mutually share some of the same biochemical processes and mechanisms as well as the fact that they can each affect some of the same diseases and maladies.
    Medical Hypotheses 08/2011; 77(5):765-72. DOI:10.1016/j.mehy.2011.07.033 · 1.07 Impact Factor
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    • "One set of evidence is that several Global reduction in mortality rates with vitamin D WB Grant diseases linked to low serum 25(OH)D levels often precede Alzheimer's disease. Such diseases include CVD, diabetes mellitus, depression, dental caries, osteoporosis and periodontal disease (Grant, 2009a). A second is that low vitamin D has been associated with cognitive impairment (Llewellyn et al., 2011), often the first sign that Alzheimer's disease is developing. "
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    ABSTRACT: The goal of this work is to estimate the reduction in mortality rates for six geopolitical regions of the world under the assumption that serum 25-hydroxyvitamin D (25(OH)D) levels increase from 54 to 110 nmol/l. This study is based on interpretation of the journal literature relating to the effects of solar ultraviolet-B (UVB) and vitamin D in reducing the risk of disease and estimates of the serum 25(OH)D level-disease risk relations for cancer, cardiovascular disease (CVD) and respiratory infections. The vitamin D-sensitive diseases that account for more than half of global mortality rates are CVD, cancer, respiratory infections, respiratory diseases, tuberculosis and diabetes mellitus. Additional vitamin D-sensitive diseases and conditions that account for 2 to 3% of global mortality rates are Alzheimer's disease, falls, meningitis, Parkinson's disease, maternal sepsis, maternal hypertension (pre-eclampsia) and multiple sclerosis. Increasing serum 25(OH)D levels from 54 to 110 nmol/l would reduce the vitamin D-sensitive disease mortality rate by an estimated 20%. The reduction in all-cause mortality rates range from 7.6% for African females to 17.3% for European females. Reductions for males average 0.6% lower than for females. The estimated increase in life expectancy is 2 years for all six regions. Increasing serum 25(OH)D levels is the most cost-effective way to reduce global mortality rates, as the cost of vitamin D is very low and there are few adverse effects from oral intake and/or frequent moderate UVB irradiance with sufficient body surface area exposed.
    European journal of clinical nutrition 07/2011; 65(9):1016-26. DOI:10.1038/ejcn.2011.68 · 2.71 Impact Factor
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    • "Dementia ( Buell et al . , 2010 ; Grant , 2009 ) and in particular , Alzhei - mer ' s disease have also been linked with low 25OHD levels ( Evatt et al . , 2008 ) . "
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    ABSTRACT: A role for vitamin D in brain development and function has been gaining support over the last decade. Multiple lines of evidence suggest that this vitamin is actually a neuroactive steroid that acts on brain development, leading to alterations in brain neurochemistry and adult brain function. Early deficiencies have been linked with neuropsychiatric disorders, such as schizophrenia, and adult deficiencies have been associated with a host of adverse brain outcomes, including Parkinson's disease, Alzheimer's disease, depression and cognitive decline. This review summarises the current state of research on the actions of vitamin D in the brain and the consequences of deficiencies in this vitamin. Furthermore, we discuss specific implications of vitamin D status on the neurotransmitter, dopamine.
    Molecular and Cellular Endocrinology 06/2011; 347(1-2):121-7. DOI:10.1016/j.mce.2011.05.014 · 4.41 Impact Factor
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