The Yield of First-Time Endoscopic Ultrasonography in Screening Individuals at a High Risk of Developing Pancreatic Cancer
ABSTRACT Approximately 10-15% of all pancreatic cancers (PCs) may be hereditary in origin. We investigated the use of endoscopic ultrasonography (EUS) for the screening of individuals at high risk for developing PC. In this paper the results of first-time screening with EUS are presented.
Those eligible for screening in this study were first-degree family members of affected individuals from familial pancreatic cancer (FPC) families, mutation carriers of PC-prone hereditary syndromes, individuals with Peutz-Jeghers syndrome, and mutation carriers of other PC-prone hereditary syndromes with clustering (> or =2 cases per family) of PC. All individuals were asymptomatic and had not undergone EUS before.
Forty-four individuals (M/F 18/26), aged 32-75 years underwent screening with EUS. Thirteen were from families with familial atypical multiple-mole melanoma (FAMMM), 21 with FPC, 3 individuals were diagnosed with hereditary pancreatitis, 2 were Peutz-Jeghers patients, 3 were BRCA1 and 2 were BRCA2 mutation carriers with familial clustering of PC, and 1 individual had a p53 mutation. Three (6.8%) patients had an asymptomatic mass lesion (12, 27, and 50 mm) in the body (n=2) or tail of the pancreas. All lesions were completely resected. Pathology showed moderately differentiated adenocarcinomas with N1 disease in the two patients with the largest lesions. EUS showed branch-type intraductal papillary mucinous neoplasia (IPMN) in seven individuals.
Screening of individuals at a high risk for PC with EUS is feasible and safe. The incidence of clinically relevant findings at first screening is high with asymptomatic cancer in 7% and premalignant IPMN-like lesions in 16% in our series. Whether screening improves survival remains to be determined, as does the optimal screening interval with EUS.
Conference Paper: A speech data base at the united states air force academy[Show abstract] [Hide abstract]
ABSTRACT: The Department of Electrical Engineering at the United States Air Force Academy is presently building a speech data base which will consist of selected speech groupings from 1000 of the Academy faculty and students. Data collection is automatic and supervised by computer programs which request information on speaker background, accents, age, etc. and run the actual data collection procedures. The information on individual speakers is placed onto a computer permanent file and is also written onto one channel of the data base tape. Data is encoded onto four channels of Beta format videotape. The data consists of: Pulse code modulated (PCM) speech from a high-quality capacitor microphone, PCM speech from a standard United States Air Force close talk microphone, analog speech from an electroglottograph, and encoded speaker background information.Acoustics, Speech, and Signal Processing, IEEE International Conference on ICASSP '86.; 05/1986
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ABSTRACT: Introducing the concept of equivalent currents, this paper proposes a very simple mathematical model for a magnetically-saturated controllable reactor (MSCR). When the primary windings of two identical transformers are positively series and the secondary windings are negatively series, an equivalent circuit for such kind of reactors can be thus derived. This circuit exactly manifests the physical discipline of the mathematical model. Based on the power system blockset (PSB) of Matlab, a simulation model for a MSCR is constructed. Subsequently, a simulation analysis is demonstrated. The results confirm the presented method.Electrical Machines and Systems, 2003. ICEMS 2003. Sixth International Conference on; 12/2003
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ABSTRACT: CO-TPD spectra of CO/Cu(+)/FER system were investigated and analyzed by a combination of experimental and theoretical techniques. Three Cu(+) site types characterized by adsorption energies -122, -76, and -59 kJ/mol were found using a combined quantum mechanical/interatomic potential function method. Three Cu(+) site types with CO adsorption energies -121, -86, and -62 kJ/mol can be distinguished from the analysis of TRD spectra of CO/Cu(+)/FER, TPD spectra call be interpreted in terms of the computational results: CO desorbs first from the Cu(+) sites in the vicinity of two framework AlO(4) tetrahedra, followed by desorption from Cu(+) sites in the perpendicular channel cavity. Sites in the main channel and oil the intersection have the largest desorption energy. Information about the framework aluminum distribution in FER can be also obtained from the analysis of CO-TPD spectra.01/2005: pages 925-932; Elsevier Science Bv., ISBN: 0167-2991 0-444-52082-1