Vitamin D for Treatment and Prevention of Infectious Diseases: A Systematic Review of Randomized Controlled Trials

Division of Infectious Diseases, Department of Medicine, Emory University School of Medicine, Atlanta, Georgia 30030, USA.
Endocrine Practice (Impact Factor: 2.59). 07/2009; 15(5):438-49. DOI: 10.4158/EP09101.ORR
Source: PubMed

ABSTRACT To review the existing human controlled intervention studies of vitamin D as adjunctive therapy in settings of infection and provide recommendations for design and implementation of future studies in this field on the basis of the evidence reviewed.
We conducted a systematic review of randomized controlled clinical trials that studied vitamin D for treatment or prevention of infectious diseases in humans. Studies from 1948 through 2009 were identified through search terms in PubMed and Ovid MEDLINE.
Thirteen published controlled trials were identified by our search criteria. Ten trials were placebo controlled, and 9 of the 10 were conducted in a rigorous double-blind design. The selected clinical trials demonstrated substantial heterogeneity in baseline patient demographics, sample size, and vitamin D intervention strategies. Serious adverse events attributable to vitamin D supplementation were rare across all studies. On the basis of studies reviewed to date, the strongest evidence supports further research into adjunctive vitamin D therapy for tuberculosis, influenza, and viral upper respiratory tract illnesses. In the selected studies, certain aspects of study design are highlighted to help guide future clinical research in the field.
More rigorously designed clinical trials are needed for further evaluation of the relationship between vitamin D status and the immune response to infection as well as for delineation of necessary changes in clinical practice and medical care of patients with vitamin D deficiency in infectious disease settings.

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Available from: Vin Tangpricha, Aug 15, 2015
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    • "Given the data collected from previous studies, one would expect that supplementation with vitamin D would lead to faster eradication of the disease. A recent systematic review of randomized-controlled trials [26] showed mixed results with regard to vitamin D supplementation, urging for more data to be collected before any definitive conclusion could be reasonably made. "
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    ABSTRACT: Objective To investigate the impacts of vitamin D status, supplementation and vitamin D receptor (VDR) gene polymorphisms on tuberculosis (TB). Methods We conducted a systematic review of published studies pertaining to case-control and randomized-control trials from 2002 to 2014 using the PubMed database. Results and conclusion: Individuals with TB have lower vitamin D status than healthy individuals. Some VDR gene polymorphisms are associated with increased susceptibility to TB while others may not. Supplementation with vitamin D leads to improved clinical outcomes. However, further studies with a larger patient population and different ethnicities are needed to confirm these effects.
    12/2014; 1(4). DOI:10.1016/j.jcte.2014.08.001
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    • "More unbiased large cohort studies are needed, since a recent meta-analysis concluded that administration of vitamin D diminishes overall allcause mortality (Autier and Gandini, 2007). The conclusion from another meta-analysis reviewing different vitamin D trials in the treatment of infectious diseases, including tuberculosis, influenza and viral upper respiratory tract infection, was that more rigorously designed clinical trials are needed to further evaluate the relationship between vitamin D status and the immune response to infection (Yamshchikov et al., 2009). "
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    ABSTRACT: In addition to its essential role in calcium homeostasis and bone metabolism, vitamin D has a diverse range of biological actions, including induction of cell differentiation, inhibition of cell growth, immunomodulation and control of hormonal systems. Vitamin D plays an immunoregulatory role in both the innate and adaptive immune systems. The active metabolite of the vitamin D endocrine system, 1,25-dihydroxyvitamin D (calcitriol), exerts pleiotropic effects through its interaction with the vitamin D receptor. Low vitamin D status in humans has been implicated in the etiology of neoplasia, autoimmune disease, cardiovascular disorders and infectious diseases. This review focuses on vitamin D and its effects on immune function, particularly in humans, with the aim to encourage further exploration in the veterinary field.
    The Veterinary Journal 06/2012; 194(1). DOI:10.1016/j.tvjl.2012.05.022 · 2.17 Impact Factor
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    • "Détérioration de la fonction cognitive Annweiler et collab., 39 2009 Synthèse critique Aucune association évidente entre la fonction cognitive et la 25(OH)D, mais une hétérogénéité considérable; les études d'interventions ne sont pas uniformes. Certaines maladies infectieuses Yamshchikov et collab., 40 2009 Synthèse critique Les données probantes sont les plus convaincantes pour la tuberculose, la grippe et les maladies des voies respiratoires supérieures d'origine virale; hétérogénéité considérable. "
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