Article

Effect of xenotransplantation of cell cultures enriched with stem and progenitor cells on hormonal profile of rats with abdominal cryptorchism.

V. I. Kulakov Research Center of Obstetrics, Gynecology, and Perinatology, Federal Agency of Medical Technologies, Russia.
Bulletin of Experimental Biology and Medicine (impact factor: 0.27). 11/2008; 146(4):517-21. pp.517-21
Source: PubMed

ABSTRACT We present the results of application of cell cultures enriched with stem and progenitor cells for the treatment of experimental abdominal cryptorchism in outbred albino rats. Xenotransplantation of human fetal enriched cell cultures was performed to animals with experimental cryptorchism during orchiolysis. Total testosterone, luteinizing and follicle-stimulating hormones were assayed by immunochemiluminescent method. It was found that xenotransplantation of cell cultures enriched with stem and progenitor cells normalized the level of total testosterone, decreased the concentrations of gonadotropic hormones, reduced hyperplasia of Leydig cells and the number of chromaffin granules, and restored normochromism of Leydig cells nuclei.

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Keywords

cell cultures enriched
 
experimental abdominal cryptorchism
 
experimental cryptorchism
 
gonadotropic hormones
 
human fetal enriched cell cultures
 
Leydig cells
 
Leydig cells nuclei
 
luteinizing
 
outbred albino rats
 
progenitor cells
 
progenitor cells normalized
 
total testosterone
 
xenotransplantation