Informant-based Dementia Screening in a Population-based Sample of African Americans

Department of Neurology & Psychiatry, School of Medicine, St Louis University, 1438 South Grand Boulevard, St Louis, MO 63104, USA.
Alzheimer disease and associated disorders (Impact Factor: 2.44). 04/2009; 23(2):117-23. DOI: 10.1097/WAD.0b013e318190a709
Source: PubMed


An informant-based screening tool for dementia may be useful in population-based studies of minority populations.
Investigate the feasibility of screening for very mild dementia in a community sample of African Americans using an informant-based screening tool (AD8).
Cohort study.
One hundred forty-seven persons from the African American Health (AAH) project were screened for dementia; 61 of 93 who were invited had follow-up clinical assessments for dementia diagnosis.
The AD8, Mini-Mental State Examination, Short Blessed Test, Brief Instrument for Dementia Detection, and a neuropsychologic battery were administered at visit 1. The Clinical Dementia Rating (CDR) was administered at visit 2 by clinicians blinded to visit 1 results; the presence of dementia was determined by a CDR greater than 0.
Four hundred sixty-five individuals from the AAH cohort were sent a letter describing the study and, among this group, 252 individuals were contacted by phone to request participation in this study. Six percent (14/252) of the participants contacted by phone were unable to identify an informant (required for the AD8). One hundred fifty individuals agreed by phone to participate of which 2% (n=3) did not have an informant available at the time of participation. The AD8 alone was effective at discriminating between CDR 0 and CDR 0.5 (area under the curve=0.847; P<0.001; 95% confidence interval, 0.73-0.96).
A brief informant-based instrument, the AD8, has high sensitivity and specificity for distinguishing CDR 0 from CDR 0.5 in the community. Informant availability may not be a barrier for using the AD8 in an African American community sample; however, further study in larger samples with a higher response rate, different community settings (eg, community clinics), and among older age groups (eg, age 75+) is warranted to confirm this.

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    • "The AD8 uses informant information; the absence of an observant informant may limit use in certain clinical situations. However, informant interviews can be successfully applied in populations with lower educational attainment (Galvin et al., 2007a; Espinosa et al., 2008; Malmstrom et al., 2009). Additionally, the AD8 can be used as a patient interview in the absence of an informant (Galvin et al., 2007a) and can be administered in person or by phone (Galvin et al., 2006). "
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