Normalizing Memory Recall in Fibromyalgia With Rehearsal: A Distraction-Counteracting Effect

Rush Medical College, Chicago, Illinois, USA.
Arthritis & Rheumatology (Impact Factor: 7.87). 07/2009; 61(6):740-4. DOI: 10.1002/art.24559
Source: PubMed

ABSTRACT To examine the impact of distraction on the retention of rehearsed information in patients with fibromyalgia syndrome (FMS).
Data refer to the neurocognitive examination of 134 patients (91 with FMS and 43 control subjects) presenting with memory loss. Four neurocognitive measures free of distraction, along with 2 measures with added distraction, were completed. Differences in the retention of rehearsed and unrehearsed information with a source of distraction present were calculated.
Patients with FMS showed normal cognitive functioning on verbal memory tests free of distraction. Adding a source of distraction caused unrefreshed information to be lost at a disproportionate rate in patients with FMS. Over 87% of patients with FMS scored in the impaired range on a task of unrehearsed verbal memory. Adding a source of distraction to well-rehearsed information produced a normal rate of recall in FMS.
Rehearsal mechanisms are intact in patients with FMS and play beneficial roles in managing interference from a source of distraction. In the absence of rehearsal, a source of distraction added to unrefreshed information signals a remarkable level of cognitive deficit in FMS that goes undetected by conventionally relied-upon neurocognitive measures. We present a theory to promote understanding of the cognitive deficit of people with FMS based on reduced speed of lexical activation and poor recall after distraction.

  • [Show abstract] [Hide abstract]
    ABSTRACT: Patients with fibromyalgia often report forgetfulness as well as declines in cognitive function, memory, and mental alertness-symptoms that have been termed "fibrofog" in popular and electronic media as well as in professional literature. "Fibrofog" is the subjectively experienced cognitive dysfunction associated with fibromyalgia and is a clinically important yet comparatively less well-studied aspect of the disorder; it includes loss of mental clarity (mental fogginess) as well as attention and memory impairment. Although until recently cognitive symptoms have been largely ignored, these symptoms can be more disturbing than the widespread pain and can change these patients' lives, sometimes dramatically so. Whereas widespread musculoskeletal pain, tenderness, and fatigue may be the hallmark symptoms of fibromyalgia, patients rank cognitive dysfunction highly in terms of disease impact. This review addresses (1) the prevalence of self-reported cognitive disturbances in fibromyalgia, (2) the clinical presentation of fibrofog, (3) neuropsychological test performance, with particular attention to discrepancies between self-report and test results, (3) clinical correlates of impaired cognitive function in fibromyalgia, (4) neurobiology relevant to cognitive disturbances in fibromyalgia, and (5) clinical management of fibrofog. Although the pathophysiology of fibromyalgia remains an enigma, evidence suggests that it may be a brain disorder, with cognitive deficits ("fibrofog") reflecting disturbed centrally mediated processes.
    Rheumatology International 01/2015; DOI:10.1007/s00296-014-3208-7 · 1.63 Impact Factor
  • Source
    [Show abstract] [Hide abstract]
    ABSTRACT: To view enhanced content go to Received: August 23, 2014 Ó The Author(s) 2014. This article is published with open access at ABSTRACT Introduction: Patients with fibromyalgia
    10/2014; DOI:10.1007/s40122-014-0028-0
  • [Show abstract] [Hide abstract]
    ABSTRACT: We review recent heat capacity and magnetotransport experiments on GaAs/AlGaAs heterostructures containing multilayer two-dimensional electron systems (2DESs) in the quantum Hall regime. Emphasis in this article is on the study of the heat capacity near Landau level filling factor ν=1. We also present a detailed survey of the development of the quantum Hall effect in tilted-magnetic fields for ν≲2. Among the novel phenomena we address is the strong coupling between the nuclear spins and the electrons associated with the spin phase transitions of the 2DES at ν=4/3 and near ν=1. To cite this article: S. Melinte et al., C. R. Physique 3 (2002) 667–676.
    Comptes Rendus Physique 07/2002; 3(6):667-676. DOI:10.1016/S1631-0705(02)01355-5 · 1.64 Impact Factor


1 Download