Salt and high blood pressure

Departments of Medicine and Community Health Sciences, University of Calgary, Calgary, Alberta, Canada.
Clinical Science (Impact Factor: 5.6). 08/2009; 117(1):1-11. DOI: 10.1042/CS20080207
Source: PubMed


HBP (high blood pressure) is the leading risk of death in the world. Unfortunately around the world, blood pressure levels are predicted to become even higher, especially in developing countries. High dietary salt is an important contributor to increased blood pressure. The present review evaluates the association between excess dietary salt intake and the importance of a population-based strategy to lower dietary salt, and also highlights some salt-reduction strategies from selected countries. Evidence from diverse sources spanning animal, epidemiology and human intervention studies demonstrate the association between salt intake and HBP. Furthermore, animal studies indicate that short-term interventions in humans may underestimate the health risks associated with high dietary sodium. Recent intervention studies have found decreases in cardiovascular events following reductions in dietary sodium. Salt intake is high in most countries and, therefore, strategies to lower salt intake could be an effective means to reduce the increasing burden of HBP and the associated cardiovascular disease. Effective collaborative partnerships between governments, the food industry, scientific organizations and healthcare organizations are essential to achieve the WHO (World Health Organization)-recommended population-wide decrease in salt consumption to less than 5 g/day. In the milieu of increasing cardiovascular disease worldwide, particularly in resource-constrained low- and middle-income countries, salt reduction is one of the most cost-effective strategies to combat the epidemic of HBP, associated cardiovascular disease and improve population health.

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    • "Correspondingly , the theca cells secrete keratinocyte growth factor (KGF) and granulosa cells secrete c-kit, which act in a paracrine fashion to control preantral follicle growth and development (Hsueh et al., 2000). High salt intake disrupts normal physiological functions, causing hypertension, cardiovascular and chronic kidney diseases (Appel et al., 2011; Mohan and Campbell, 2009). Strazzullo et al. (2009) demonstrated that excess salt consumption is related to enhanced risk of stroke and cardiovascular disease. "
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    ABSTRACT: Many human disorders induce high salinity in tissues and organs, interfering with their normal physiological functions. Using a mouse model, we demonstrated that high salt intake caused infertility. Specifically, we established that high salinity dramatically affects ovarian follicle development and the extent of follicular atresia. However, it did not significantly influence the primordial follicles. TUNEL assays revealed that high salt intake inhibited follicle development by inducing the granulosa and theca cells that surround the oocytes to undergo apoptosis. Furthermore, immunohistological staining for the proliferation markers Ki67 and PH3 showed that high salt intake also repressed granulosa cell proliferation. In vitro testing of granulosa cells also confirmed that high salt significantly repressed cell proliferation and promoted cell apoptosis. In summary, high salt consumption negatively impacts reproductive functions in female mice by interfering with ovarian folliculogenesis. Copyright © 2015 Elsevier GmbH. All rights reserved.
    Annals of Anatomy - Anatomischer Anzeiger 03/2015; 200. DOI:10.1016/j.aanat.2015.02.009 · 1.48 Impact Factor
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    • "Most (75-80%) of this sodium comes from processed foods [5]. There is strong evidence that excess sodium intake is a risk factor for hypertension, stroke, and cardiovascular disease [6,7]. High blood pressure, which is directly linked with high sodium intake, is considered the leading preventable risk factor for death in the world [8]. "
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    ABSTRACT: Introduction In many countries including Canada, excess consumption of dietary sodium is common, and this has adverse implications for population health. Socio-economic inequities in sodium consumption seem likely, but research is limited. Knowledge of socio-economic inequities in sodium consumption is important for informing population-level sodium reduction strategies, to ensure that they are both impactful and equitable. Methods We examined the association between socio-economic indicators (income and education) and sodium, using two outcome variables: 1) sodium consumption in mg/day, and 2) reported use of table salt, in two national surveys: the 1970/72 Nutrition Canada Survey and the 2004 Canadian Community Health Survey, Cycle 2.2. This permitted us to explore whether there were any changes in socio-economic patterning in dietary sodium during a time period characterized by modest, information-based national sodium reduction efforts, as well as to provide baseline information against which to examine the impact (equitable or not) of future sodium reduction strategies in Canada. Results There was no evidence of a socio-economic inequity in sodium consumption (mg/day) in 2004. In fact findings pointed to a positive association in women, whereby women of higher education consumed more sodium than women of lower education in 2004. For men, income was positively associated with reported use of table salt in 1970/72, but negatively associated in 2004. Conclusions An emerging inequity in reported use of table salt among men could reflect the modest, information-based sodium reduction efforts that were implemented during the time frame considered. However, for sodium consumption in mg/day, we found no evidence of a contemporary inequity, and in fact observed the opposite effect among women. Our findings could reflect data limitations, or they could signal that sodium differs from some other nutrients in terms of its socio-economic patterning, perhaps reflecting very high prevalence of excess consumption. It is possible that socio-economic inequities in sodium consumption will emerge as excess consumption declines, consistent with fundamental cause theory. It is important that national sodium reduction strategies are both impactful and equitable.
    International Journal for Equity in Health 06/2014; 13(1):44. DOI:10.1186/1475-9276-13-44 · 1.71 Impact Factor
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    • "One of the main causes of high blood pressure is excess dietary salt intake. Excess salt intake progressively elevates blood pressure levels throughout life, which greatly increases the risks of vascular diseases [5,6] and is likely to be responsible for about half of the disease burden ascribed to high blood pressure [7]. Whilst there is still debate about the impact of salt reduction on cardiovascular disease, the totality of the evidence is convincing [8-10]. "
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    ABSTRACT: There is broad consensus that diets high in salt are bad for health and that reducing salt intake is a cost-effective strategy for preventing chronic diseases. The World Health Organization has been supporting the development of salt reduction strategies in the Pacific Islands where salt intakes are thought to be high. However, there are no accurate measures of salt intake in these countries. The aims of this project are to establish baseline levels of salt intake in two Pacific Island countries, implement multi-pronged, cross-sectoral salt reduction programs in both, and determine the effects and cost-effectiveness of the intervention strategies. Intervention effectiveness will be assessed from cross-sectional surveys before and after population-based salt reduction interventions in Fiji and Samoa. Baseline surveys began in July 2012 and follow-up surveys will be completed by July 2015 after a 2-year intervention period.A three-stage stratified cluster random sampling strategy will be used for the population surveys, building on existing government surveys in each country. Data on salt intake, salt levels in foods and sources of dietary salt measured at baseline will be combined with an in-depth qualitative analysis of stakeholder views to develop and implement targeted interventions to reduce salt intake. Salt reduction is a global priority and all Member States of the World Health Organization have agreed on a target to reduce salt intake by 30 % by 2025, as part of the global action plan to reduce the burden of non-communicable diseases. The study described by this protocol will be the first to provide a robust assessment of salt intake and the impact of salt reduction interventions in the Pacific Islands. As such, it will inform the development of strategies for other Pacific Island countries and comparable low and middle-income settings around the world.
    BMC Public Health 02/2014; 14(1):107. DOI:10.1186/1471-2458-14-107 · 2.26 Impact Factor
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