Article

Epigenetic Events Highlight the Challenge of Validating Prognostic Biomarkers During the Clinical and Biologic Evolution of Prostate Cancer

Institute for Genome Sciences and Policy, Duke University Medical Center, Durham, NC.
Journal of Clinical Oncology (Impact Factor: 18.43). 06/2009; 27(19):3088-90. DOI: 10.1200/JCO.2008.20.9783
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    • "This is particularly true in humans and agricultural crops, where the need for understanding epigenetic risk is the greatest [20-27]. Without knowledge about the molecular basis for the transgenerational inheritance or generational reprogramming of defined epigenetic risk factors that contribute to disease, it is difficult to design effective targeted therapeutics for humans or to knowledgably alter breeding programs for crops that will avoid the onset of a disease phenotype [28-32]. "
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