Protease inhibitor monotherapy is not associated with increased viral replication in lymph nodes

AIDS (London, England) (Impact Factor: 5.55). 05/2014; 28(12). DOI: 10.1097/QAD.0000000000000312
Source: PubMed


There are concerns about residual viremia in sanctuary sites among patients on protease inhibitor monotherapy, so we aimed to study viro-immunological parameters in tonsil's lymphoid tissue of patients on HAART and on protease inhibitor monotherapy. Despite fully suppressed serum HIV viral load, we found viral replication in both groups; in addition, more patients had detectable proviral DNA among those on HAART, compared to those on protease inhibitor monotherapy (P = 0.08), supporting the absence of a deleterious effect of protease inhibitor monotherapy.

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