Risk factors for sporadic colorectal cancer in southern Chinese

Department of Colorectal Surgery, Gastrointestinal Institute of Sun Yat-Sen University, The Sixth Affiliated Hospital of Sun Yat-Sen University, Guangzhou, Guangdong Province, China.
World Journal of Gastroenterology (Impact Factor: 2.37). 05/2009; 15(20):2526-30. DOI: 10.3748/wjg.15.2526
Source: PubMed


To investigate the role of smoking, alcohol drinking, family history of cancer, and body mass index (BMI) in sporadic colorectal cancer in southern Chinese.
A hospital-based case-control study was conducted from July 2002 to December 2008. There were 706 cases and 723 controls with their sex and age (within 5 years) matched. An unconditional logistic regression model was used to analyze the association between smoking, alcohol drinking, family history of cancer, BMI and sporadic colorectal cancer.
No positive association was observed between smoking status and sporadic colorectal cancer risk. Compared with the non alcohol drinkers, the current and former alcohol drinkers had an increased risk of developing sporadic colorectal cancer (CRC) (adjusted OR = 8.61 and 95% CI = 6.15-12.05; adjusted OR = 2.30, 95% CI = 1.27-4.17). Moreover, the increased risk of developing sporadic CRC was significant in those with a positive family history of cancer (adjusted OR = 1.62, 95% CI = 1.12-3.34) and in those with their BMI >or= 24.0 kg/m(2) (adjusted OR = 1.39, 95% CI = 1.10-1.75). Stratification analysis showed that the risk of developing both colon and rectal cancers was increased in current alcohol drinkers (adjusted OR = 7.60 and 95% CI = 5.13-11.25; adjusted OR = 7.52 and 95% CI = 5.13-11.01) and in those with their BMI >or= 24.0 kg/m(2) (adjusted OR = 1.38 and 95% CI = 1.04-1.83; adjusted OR = 1.35 and 95% CI = 1.02-1.79). The risk of developing colon cancer, but not rectal cancer, was found in former alcohol drinkers and in those with a positive family history of cancer (adjusted OR = 2.51 and 95% CI = 1.24-5.07; adjusted OR = 1.82 and 95% CI = 1.17-2.82).
Alcohol drinking, high BMI (>or= 24.0 kg/m(2)) and positive family history of cancer are the independent risk factors for colorectal cancer in southern Chinese.

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    • "The data from the municipal death registry system in cities of China show that the death rate of CRC has increased in recent decades and that CRC is becoming a growing health problem in cities of China (Song et al., 2008). The epidemiological studies of sporadic CRC have established that many etiologic factors, including age, sex, smoking status, alcohol consumption and family history of cancer, may influence the risk of developing cancer and its clinical outcome (Wei et al., 2009). Aside from the traditional risk factors, an effort has been made to detect genetic factors that contribute to the risk of colorectal cancer development. "
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