Article

Sarcomatoid carcinoma of the penis: Clinicopathologic features

Indian Journal of Urology 05/2008; 24(2):267-8. DOI: 10.4103/0970-1591.40630
Source: PubMed

ABSTRACT Sarcomatoid carcinomas are biphasic tumors, which can occur at any site in the human body. Very few cases have been reported in the literature as arising from the penis. A few studies consider these tumors as a variant of squamous cell carcinoma or a metaplastic differentiation of the mesenchyme. Their clinical behavior is aggressive with both blood borne and lymphatic metastases. Treatment is by surgical excision, and dissected lymph nodes have shown both epithelial and sarcomatous components. We report a 50-year-old gentleman, with a sarcomatoid carcinoma of the penis, which was confirmed immunopathologically. The rarity of this entity makes it a clinicopathologic curiosity.

0 Followers
 · 
109 Views
  • Source
    [Show abstract] [Hide abstract]
    ABSTRACT: Penile cancer is an extremely rare form of urological cancer that usually originates in the epithelium of the inner preputium or glans. Major etiological factors include phimosis, poor penile hygiene and smoking. Nearly 95% of penile cancers are squamous cell carcinomas and usually occur in the sixth decade of life. The disease exhibits two variants, namely metastatic and atypical disease. Squamous differentiation may also present with mucinous metaplasia. An extremely limited number of case reports on penile cancer are available in the literature. The present study reports the case of a 39-year-old patient with penile mucinous adenocarcinoma who was admitted with the complaint of perineal discharge, which is, to the best of our knowledge, the first case in the literature. The patient underwent total penectomy and inguinal lymph node dissection. The tumor was staged as T4N1M0, according to the European Association of Urology's tumor-node-metastasis classification system. The patient was treated with pelvic radiotherapy and six cycles of systemic neoadjuvant chemotherapy with cisplatin and paclitaxel simultaneously, over a period of four months. After nine months of follow-up the patient succumbed to the disease due to widespread metastases.
    Oncology letters 03/2015; 9(3):1293-1296. DOI:10.3892/ol.2014.2839 · 0.99 Impact Factor
  • [Show abstract] [Hide abstract]
    ABSTRACT: Penile cancer is a rare disease with devastating physical and psychological effects on patients. The aim of this review is to update specialist nurses regarding the epidemiology, aetiology and management.
    International Journal of Urological Nursing 10/2011; 5(3):97 - 106. DOI:10.1111/j.1749-771X.2011.01126.x · 0.19 Impact Factor
  • [Show abstract] [Hide abstract]
    ABSTRACT: Sarcomatoid carcinoma or carcinosarcoma of the penis is a rare entity with 36 cases reported in the literature. A 61-year-old male presented with swelling in the glans and shaft of the penis with bilateral inguinal lymph node metastases. He underwent total penectomy with bilateral inguinal block dissection. Histopathology revealed sarcomatoid carcinoma of the Penis with bilateral inguinal lymph node metastases. The patient later developed bilateral lung metastases in 6 months and was succumbed to death. Sarcomatoid carcinoma or carcinosarcoma is a rare malignancy with poor prognosis.
    Indian Journal of Surgery 08/2014; 76(4):316-8. DOI:10.1007/s12262-013-0965-6 · 0.27 Impact Factor