Peroral dual scope for natural orifice transluminal endoscopic surgery (NOTES) gastrotomy closure.
ABSTRACT Although transgastric intraperitoneal surgery is feasible both in experimental models and humans, secure gastrotomy closure remains challenging. As there is still no method that is simple, reliable, inexpensive, and effective, we aimed to evaluate the feasibility, efficacy, and safety of a novel endoscopic approach to this issue that intends to ensure secure healing by obtaining full thickness gastric wall apposition without requiring specialized instrumentation.
Six pigs underwent general anesthesia followed by peritoneoscopy through a 12-mm gastrotomy by a double-channel endoscope. Gastrotomy closure was performed by our innovative technique. In short, this involves the insertion of a second single-channel gastroscope alongside the NOTES gastroscope. Both scopes are then worked in tandem within the stomach by separate operators using conventional endoscopic graspers and an endoclip device. The first animal was used to ascertain feasibility and standardize the technical steps, whereas the other five were survived. Postoperative follow-up then included endoscopy 1 week later and repeat endoscopy, laparoscopy, and necropsy on day 14.
All closures were immediately successful. Postoperatively, each animal demonstrated appropriate weight gain and behavioral pattern without overt postoperative complication. Necropsy showed normal healing at the gastrotomy site although there were signs of minor peritoneal irritation and infection in 2 pigs.
This transoral dual-scope clipping method of gastrotomy closure after NOTES, as well as the general concept of employing 2 separate instruments at the same time perorally, is proven technically feasible, safe, and effective in this model.
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ABSTRACT: Animal models are key elements of surgical research and promotion of new techniques. Inanimate models, anatomical specimens, and living animals are all necessary to solve the various problems encountered by the advent of a new surgical technique. The development of Natural Orifice Transluminal Endoscopic Surgery (NOTES) procedures is a representative model. Over 400 experimental procedures were performed in inanimate models, ex vivo tissues and animals to solve all problems faced by the development of NOTES surgery: peritoneal access, gastrotomy closure, exposure, retraction, dissection as well as education to start this new procedure. The successive use of all models allows to identify the ideal solution for each problem and to precisely define the safest and most reliable option to apply the new technique in patients. It allowed to perform the first transvaginal and transgastric cholecystectomy in patients in a safe way. Animal experimentation remains necessary as even sophisticated computer-based solutions are unable to model all interactions between molecules, cells, tissues, organisms, and their environment. Animal research is required in many areas to validate new technologies, develop training, let alone its major goal (namely to avoid using patients for experimentation) which is to be the first "model" for the surgeon.Langenbeck s Archives of Surgery 09/2013; · 1.89 Impact Factor
Article: The ANUBIS™ project.[Show abstract] [Hide abstract]
ABSTRACT: The aims of the ANUBIS™ project developed in IRCAD-Strasbourg were to evaluate the concept and the potentialities of natural orifices transluminal endoscopic surgery (NOTES), to develop a specific instrumentation, to translate the research work into clinical settings and to provide education and training. To achieve these goals, an intensive collaboration was established between IRCAD, which comprises medical staff (surgeons, gastroenterologists, gynaecologists), computer scientists and robotics engineers, and industrial partners. Between 2005 and 2008, more than 400 experimental procedures were performed on inanimate models, ex-vivo tissues, animal models and human cadavers. Cholecystectomy was defined as the procedure that would realize the translation of experimental work into the clinical setting. The first human transvaginal cholecystectomy was performed at the end of the second year of the project. Transgastric cholecystectomy followed six months later. A new concept of therapeutic flexible endoscope (Anubiscope™, Storz Endoskope,Tutlingen, Germany) was developed, and different modalities of closure of the viscerotomies were elaborated. Implementation of the experimental program into the clinical setting and translation of technological research into a finalized industrial product were achieved thanks to a rigorous, extensive and stepwise study of the potentialities of NOTES. Education and training were organized and 500 participants attended the specific courses and hands-on sessions organized at IRCAD-EITS.Minimally invasive therapy & allied technologies: MITAT: official journal of the Society for Minimally Invasive Therapy 10/2010; 19(5):257-61. · 1.33 Impact Factor
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ABSTRACT: Surgical therapy for gastric cancer involves both removal of the cancer lesion and complete lymph node dissection. Natural orifice transluminal endoscopic surgery (NOTES) is considered to represent the next revolution in surgery. Many surgeons and endoscopists believe that NOTES may be a superior alternative for early gastric cancer treatment. Sentinel node (SN) navigation surgery for gastric cancer: Single institution results of SN mapping for early gastric cancer are increasingly being considered acceptable. Furthermore, a major large-scale clinical trial of SN mapping for gastric cancer has recently been completed by The Japan Society of SN Navigation Surgery study group. They reported false negative rate of 7.0% while the sensitivity of metastasis detection based on SN status was 93%. Combination of SN biopsy and NOTES: This concept was first described by Cahill et al who proved the feasibility of lymphatic mapping and SN biopsy by NOTES. Lymphatic channel filling was immediately observable via the intraperitoneal optics. Partial resection of the stomach by hybrid NOTES: Several centers have already reported gastrectomy assisted by NOTES using the transvaginal route. However, the main problem of full-thickness resection of gastric wall remains endoscopic gastric closure. Establishing an endoscopic suturing method would be an important step toward expanding potential indications. NOTES is met with both enthusiasm and skepticism but will gain its own place as human creativity eventually provides solutions to its technical limitations. In the near future, NOTES can evolve the capacity to complement the existing armamentarium for gastric cancer surgery.World journal of gastrointestinal surgery. 06/2010; 2(6):203-6.