High-Dose Vaginal Metronidazole for Recurrent Bacterial Vaginosis-APilot Study

Departments of 1 Obstetrics and Gynecology, 2Biochemistry and Molecular Biology, and 3Infectious Diseases, Wayne State University School of Medicine, Detroit, MI.
Sexually transmitted diseases (Impact Factor: 2.75). 05/2014; 41(5):290-1. DOI: 10.1097/OLQ.0000000000000123
Source: PubMed

ABSTRACT The purpose of this study was to explore the benefit of high-dose intravaginal metronidazole as a maintenance therapy in reducing recurrence rates of bacterial vaginosis (BV).Eighteen women with a history of recurrent BV and symptomatic BV were treated with metronidazole 750 mg suppository intravaginally daily for 7 days. Those in remission by Amsel criteria received metronidazole 750 mg twice weekly for 3 months with further follow-up for 3 months. High-dose metronidazole intravaginally was associated with rare clinical recurrence during the period of use. After cessation of suppression therapy, recurrence was high.

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