Antidepressants for Depression in Patients with Dementia: A Review of the Literature

The Consultant pharmacist: the journal of the American Society of Consultant Pharmacists 04/2014; 29(4):254-63. DOI: 10.4140/TCP.n.2014.254
Source: PubMed


Objective: To evaluate the literature investigating the efficacy and safety of antidepressants for treating depression in individuals with dementia.Data Sources: A literature search was conducted using MEDLINE, PUBMED, EMBASE, and Cochrane databases from inception to May 2013 for
studies in English that evaluated the treatment of depression in patients with dementia. All relevant randomized controlled trials (RCTs) and meta-analyses were identified using the search terms “dementia” or “Alzheimer's disease,” and “depression” or “major
depressive disorder.” Reference lists from retrieved articles and practice guidelines were also searched for relevant literature.Study selection and data extraction: Only randomized, placebo-controlled trials and meta-analyses that compared an antidepressant with placebo for the
treatment of depression in patients with dementia were included.Data Synthesis: In this systematic review, 10 RCTs and 3 meta-analyses were identified that examined the efficacy and safety of antidepressants compared with placebo in treating depression in patients with dementia. The majority
of the RCTs consisted of a small sample size, and the antidepressants studied were not routinely used in practice.Conclusions: The evidence for antidepressants in the treatment of depression in patients with dementia is inconclusive. The accumulation of evidence suggests nonpharmacologic
approaches and watchful waiting be attempted for the first 8 to 12 weeks in a patient who presents with both mild-to-moderate depression and dementia. In cases of severe depression, or depression not managed through nonpharmacologic means, a trial of an antidepressant may be initiated. However,
further well-designed trials are needed to support these recommendations.

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Available from: Christine Leong, Apr 14, 2014
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