Article

HeLiVa platform: integrated heart-liver-vascular systems for drug testing in human health and disease

Stem Cell Research & Therapy (Impact Factor: 4.63). 12/2013; 4 Suppl 1:S8. DOI: 10.1186/scrt369
Source: PubMed

ABSTRACT Our project team is developing an integrated microphysiological platform with functionally connected vascular, liver and cardiac microtissues derived from a single line of human pluripotent stem cells. The platform enables functional representation of human physiology in conjunction with real-time biological readouts (via imaging and homologous reporters for all three cell phenotypes) and compatibility with high-throughput/high-content analysis. In this paper, we summarize progress made over the first year of the grant.

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