Frequency of autoimmune diseases in those suffering from vitiligo in comparison with normal population.
ABSTRACT Vitiligo is more common in people with certain autoimmune diseases. Here we studied the association between vitiligo and autoimmune diseases. In this case control study, 86 patients with vitiligo were questioned about the location of vitiligo, family history, treatment and therapeutic response. All patients were examined both clinically and with laboratory tests to detect the presence of autoimmune disorders including autoimmune thyroid disease, pernicious anemia, insulin dependent diabetes, and Systemic Lupus Erythematic (SLE) and Addison disease. We compared the prevalence of autoimmune disorder in vitiligo patients with that in a group of age-and gender-matched normal population. Average age of disease onset was 21.8 +/- 11 years; 61% of patients were female and 39% were male. The most common locations of vitiligo were hands (33.7%) and face (32.1%). The most common pattern of onset was vulgaris type (40%). Nearly one-fourth of patients had a positive family history of vitiligo. Prevalence of thyroid disorders in vitiligo patients and control group was 21.1 and 7%, respectively. The difference was statistically significant (p = 0.008). The most common autoimmune disorder in patient with vitiligo was hypothyroidism. Family history had a poor prognostic effect on response to therapy.
Article: The Epidemiology of Vitiligo[Show abstract] [Hide abstract]
ABSTRACT: Vitiligo is a common condition seen in a dermatology office, which has a variety of comorbidities. Worldwide, the prevalence of vitiligo ranges from 0.4 to 2.0 %, with regions of greater or lesser prevalence. Most studies demonstrate slightly greater prevalence in females and 50 % onset in childhood, but exceptions to these rules exist. Childhood vitiligo has been associated with atopic diathesis, halo nevi, and family history of vitiligo and autoimmunity. Post-pubescent vitiligo has been associated with greater acrofacial disease and thyroid disease, and early data supports reduced non-melanoma and melanoma skin cancer risk. Disease severity is inversely proportional to distance from the equator, and birthplace outside the USA may be somewhat protective against severe disease. This article reviews the epidemiology of vitiligo and the epidemiologic relationship of vitiligo to comorbid diseases and family history, with a focus on recent literature.03/2015; 4(1). DOI:10.1007/s13671-014-0098-6
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ABSTRACT: Vitiligo, although asymptomatic, highly compromises patients' quality of life (QoL). Therefore, an adequate evaluation of QoL is essential. Translation, cultural adaptation and validation of VitiQol (Vitiligo-specific health-related quality of life instrument) into Brazilian Portuguese. The study was conducted in two stages; the first stage was the translation and cultural/linguistic adaptation of the instrument; the second stage was the instrument's validation. The translated VitiQol showed high internal consistency (Cronbach alpha = 0.944) and high test-retest reliability and intraclass correlation coefficient=0.95 (CI 95% 0.86 - 0.98), p<0.001. There was no statistically significant difference between the means of the first completion of the VitiQoL questionnaire and the retest, p = 0.661. There was a significant correlation between VitiQoL and DLQI (r = 0.776, p <0.001) and also between VitiQoL-PB and subjects' assessment of the severity of their disease (r = 0.702, p <0.001). The impact of vitiligo on the QoL of Brazilian patients can be assessed by a specific questionnaire.Anais brasileiros de dermatologia 05/2015; 90(3):358-62. DOI:10.1590/abd1806-4841.20153684