Protective Effects of Nigella sativa on Metabolic Syndrome in Menopausal Women

Advanced Pharmaceutical Bulletin (Impact Factor: 0.88). 03/2014; 4(1):29-33. DOI: 10.5681/apb.2014.005
Source: PubMed


This study was conducted in menopausal women to determine the metabolic impact of Nigella sativa.

Thirty subjects who were menopausal women within the age limit of 45-60 were participated in this study and randomly allotted into two experimental groups. The treatment group was orally administered with N. sativa seeds powder in the form of capsules at a dose of 1g per day after breakfast for period of two months and compared to control group given placebo. Anthropometric and biochemical parameters were measured at baseline, 1st month, 2nd month and a month after treatment completed to determine their body weight, serum lipid profile and fasting blood glucose (FBG).

The treatment group showed slight reduction with no significant difference in body weight changes of the respondents. However, significant (p<0.05) improvement was observed in total cholesterol (TC), triglycerides (TG), low density lipoprotein cholesterol (LDL-C), high density lipoprotein cholesterol (HDL-C), and blood glucose (p<0.05).

These results suggested that treatment with N. sativa exert a protective effect by improving lipid profile and blood glucose which are in higher risk to be elevated during menopausal period.

Download full-text


Available from: Ramlah mohamad ibrahim, May 07, 2015
  • Source
    [Show abstract] [Hide abstract]
    ABSTRACT: The aim of this open label crossover study was to investigate the effects of Nigella sativa on reproductive health and metabolic profile of perimenopausal women in Rawang, Malaysia. Sixty nine perimenopausal women aged 45 to 65 were allocated into the experimental group treated orally with 1600mg/day of encapsulated pure powdered N. sativa compared to control groups treated with placebo for 12 weeks. At the end of study, participants underwent washout period for fourteen days before being crossed over and continued for another cycle of treatment. Participants were abstained from taking any other drugs, herbal preparations or food supplements throughout the study. Body weight, height, waist circumference, blood pressure, biochemical parameters and hormonal levels were measured at baseline and at the end of experiment for both cycles. Face to face interview was carried out at baseline and every week to check for compliance, minimize dropouts and to record reproductive health and quality of life indicators using Greene climacteric and SF-36 instruments. The treatment groups in both cycles showed significant improvement with reference to low density lipoprotein cholesterol and blood glucose (P<0.05). There were no significant differences between groups in total cholesterol, high density lipoprotein and triglyceride concentration. Treatment with N. sativa induced a significant reduction of prevalence and severity of menopausal symptomsas well as significant improvement in some components of quality of life (P<0.05). These results suggested that treatment with N. sativa exert a therapeutic and protective effect by modifying weight gain, improving lipid profile and blood glucose as well as hormonal level which is believed to play an important role in the pathogenesis of metabolic syndrome during menopause.
    Iranian Journal of Basic Medical Science 12/2014; 17(12):980-5. · 1.23 Impact Factor
  • Source

    Iranian Journal of Basic Medical Sciences 12/2014; 17(12):980-985. · 1.23 Impact Factor
  • Source
    [Show abstract] [Hide abstract]
    ABSTRACT: Abstract Introduction: Improvement of lipid abnormalities are important in the prevention of diabetes complications. The study aimed to determine the effect of nigella sativa oil extract oil on blood lipid abnormalities in patients with type 2 diabetes. Materials and Methods: In this double blind randomized clinical trial, 43 men and women with type 2 diabetes who were randomized to the intervention (n=23) and placebo (n=20) groups were studied and compared. The intervention group received 2 capsules daily, (500 mg extract of Black Seed Oil) while the control group took 2 capsules (500 mg, placebo daily) for 8 weeks, respectively. Lipid profiles were measured at the beginning and end of the intervention. Result: Mean age and body mass index of participants was 53.7±6.0 y and 28.6±5.4 kg/m2, respectively. At the end of the eighth week, the concentrations of serum triglycerides, LDL cholesterol, total cholesterol and LDL to HDL cholesterol of the intervention group were compared to the placebo group, and a significant reduction (P<0.05) was found. However concentrations of HDL cholesterol and total cholesterol to HDL cholesterol ratio, at the of the end eighth week in the intervention group and the control group showed no significant difference. Conclusion: Black Seed Oil extract improves lipid profiles in type 2 diabetic patients.
    Iranian Journal of Endocrinology and Metabolism 01/2015; 16(6).
Show more