PSILOCYBIN – summary of knowledge and new perspectives

European neuropsychopharmacology: the journal of the European College of Neuropsychopharmacology (Impact Factor: 4.37). 01/2013; 24(3). DOI: 10.1016/j.euroneuro.2013.12.006


Psilocybin, a psychoactive alkaloid contained in hallucinogenic mushrooms, is nowadays given a lot of attention in the scientific community as a research tool for modeling psychosis as well as due to its potential therapeutic effects. However, it is also a very popular and frequently abused natural hallucinogen. This review summarizes all the past and recent knowledge on psilocybin. It briefly deals with its history, discusses the pharmacokinetics and pharmacodynamics, and compares its action in humans and animals. It attempts to describe the mechanism of psychedelic effects and objectify its action using modern imaging and psychometric methods. Finally, it describes its therapeutic and abuse potential.

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Available from: Filip Tylš, Jul 21, 2014
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    • "This supports the idea that psilocin also had amnestic effects. It is well known from the literature that psilocin effects are mainly mediated through 5-HT 2A/C and 5-HT 1A receptors (Tyls et al., 2013). These receptors are widely distributed in the neocortex , basal ganglia, limbic system, and hippocampus and in the case of 5-HT 1A also in rapheal nuclei (Barnes and Sharp, 1999). "
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    ABSTRACT: The serotonergic hallucinogen psilocybin has received a lot of attention due to its potential use in clinical as well as experimental psychiatry, addictology and neurology. This text presents the results of recent clinical studies with psilocybin in the context of its historical use and summarizes the psychological and biological aspects of its effect in specific therapeutic indications. In addition it discusses the association between its psychotomimetic and therapeutic effects within the framework of the "entropic brain" theory.
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