The impact of personality on quality of life and disease activity in patients with Behcet's disease: a pilot study.
ABSTRACT The aim of this study was to examine the personality characteristics of patients with Behcet's Disease (BD) using the Temperament and Character Inventory (TCI) compared with healthy control subjects and to investigate the relationship between the temperament and character properties and quality of life, disease activity, depression and anxiety in Behcet's patients.
A total of 46 BD patients and 40 healthy subjects were included in the study. All patients and controls were determined using the TCI, Structured Clinical Interview for Diagnostic and Statistical Manual of Mental Disorders Clinical Version for Axis I disorders (SCID-CV), Beck Depression Inventory (BDI), Beck Anxiety Inventory (BAI), Quality of life (QOL) Instrument for Skin Disorders and Behcet Disease Current Activity Form (BDCAF).
BD patients demonstrated significantly lower Reward Dependence than healthy controls. Among the subscales; Explarotory Excitability, Shyness with Strangers, Attachment, Spiritual Acceptance were lower and Self-Acceptance was higher in patients compared to control subjects. Decreased quality of life and increased disease activity of the patients were correlated with increased anxiety and depression. Responsibility, Self-Forgetfulness and Transpersonal Identification were associated with quality of life while Responsibility was the major factor effecting QOL. Disease activity was not found related with TCI properties.
Temperament and Character traits of BD patients were different from healthy group that might be due to many factors like genetics, biological or socio-cultural differences. BD patients were demonstrated as materialistic, self-contained, self-confident, cold, detached, and reserved although they are not shy. Considering the different personality traits of BD patients in psychotherapeutic approaches, may have a positive impact on QOL and comorbid major depressive disorder.
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ABSTRACT: In this study, we describe a psychobiological model of the structure and development of personality that accounts for dimensions of both temperament and character. Previous research has confirmed four dimensions of temperament: novelty seeking, harm avoidance, reward dependence, and persistence, which are independently heritable, manifest early in life, and involve preconceptual biases in perceptual memory and habit formation. For the first time, we describe three dimensions of character that mature in adulthood and influence personal and social effectiveness by insight learning about self-concepts. Self-concepts vary according to the extent to which a person identifies the self as (1) an autonomous individual, (2) an integral part of humanity, and (3) an integral part of the universe as a whole. Each aspect of self-concept corresponds to one of three character dimensions called self-directedness, cooperativeness, and self-transcendence, respectively. We also describe the conceptual background and development of a self-report measure of these dimensions, the Temperament and Character Inventory. Data on 300 individuals from the general population support the reliability and structure of these seven personality dimensions. We discuss the implications for studies of information processing, inheritance, development, diagnosis, and treatment.Archives of General Psychiatry 01/1994; 50(12):975-90. · 13.75 Impact Factor
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ABSTRACT: To assess the overall impact of Behçet's syndrome (BS) on quality of life and the specific impact of the type and number of symptoms on the quality of life of adults with BS. A questionnaire was mailed to the 641 adult members of the Behçet's Syndrome Society in the UK. Participants provided information on socio-demographic characteristics, disease duration, current symptoms (mouth ulcers, genital ulcers, skin lesions, fatigue, joint problems, stomach/bowel problems, eye problems, pathergy reaction, headaches and other neurological problems), symptom control and quality of life (the EQ-5D index). Linear regression was used to test the associations of the type and number of symptoms with the EQ-5D index. Of the 447 members, 400 who returned the questionnaires had a confirmed diagnosis of BS. Of them, 362 had information on the variables selected for this analysis (76% females and 94% white British). The mean EQ-5D index was 0.47 (S.D. 0.38). Of the 10 symptoms assessed, joint problems had the strongest impact on quality of life, followed by neurological problems, pathergy reaction and stomach/bowel problems (adjusted coefficients of -0.15, -0.13, -0.11 and -0.18, respectively). Furthermore, the number of symptoms was significantly related to the EQ-5D index after adjustment for socio-demographic characteristics, disease duration and symptom control. The EQ-5D index decreased by -0.05 U for every additional symptom reported. BS has a considerable impact on quality of life. Both the type and number of symptoms affect the quality of life of adults with BS.Rheumatology (Oxford, England) 11/2010; 49(11):2165-71. · 4.44 Impact Factor
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ABSTRACT: Chronic fatigue following inflammatory diseases has been well documented. However, little is known about possible risk factors of chronic post-inflammatory fatigue. The aim of this study was to investigate whether chronic post-inflammatory fatigue after clinical remission of the disease sarcoidosis is associated with specific dimensions of personality, psychological symptoms and baseline levels of stress hormones. Thirty-seven non-fatigued and 33 fatigued patients in clinical remission of sarcoidosis were evaluated with the Temperament and Character Inventory-short form (TCI); the Symptom CheckList-90 (SCL), and the Checklist Individual Strength (CIS). Baseline levels of ACTH and cortisol were measured in plasma. Principal component analysis with orthogonal rotation (varimax) was conducted on all personality, psychological and stress hormone data in order to obtain a smaller set of components. Logistic regression was performed to associate these components with chronic post-inflammatory fatigue. Principal component analyses identified 5 components, of which two components were significantly associated with chronic post-inflammatory fatigue. The first component comprised the personality trait Harm Avoidance and all SCL-subscales except Sleep. The second component consisted of baseline levels ACTH and cortisol, and showed an inverse association with chronic post-inflammatory fatigue. The 3 other components, consisting of respectively SCL-Sleep, TCI-Novelty Seeking-Reward Dependence-Self Transcendence, and TCI-Persistence, were not significantly associated with chronic fatigue. Chronic post-inflammatory fatigue after clinical remission of sarcoidosis is associated with a triad of risk factors: a specific personality profile with profound neurotic characteristics in combination with high levels of psychological distress, and decreased baseline ACTH/cortisol levels.Journal of psychosomatic research 02/2012; 72(2):97-102. · 2.91 Impact Factor