SOX-10 expression in cutaneous myoepitheliomas and mixed tumors

Journal of Cutaneous Pathology (Impact Factor: 1.58). 12/2013; 41(4). DOI: 10.1111/cup.12279
Source: PubMed


SOX-10 can be demonstrated by immunohistochemistry in salivary gland myoepitheliomas, but its expression in cutaneous myoepitheliomas and in cutaneous mixed tumors with prominent myoepithelial cells has not been studied.
We assessed the staining pattern of SOX-10 in 5 cutaneous myoepitheliomas and 6 cutaneous mixed tumors with a prominent myoepithelial component among both the myoepithelial cells and cells lining lumens. Additionally, we examined the staining of S100, microphthalmia-associated transcription factor (MiTF) keratin cocktail, HMK903, smooth muscle actin (SMA) and epithelial membrane antigen (EMA).
SOX-10 positivity was seen in 3/5 (60%) cutaneous myoepitheliomas and in the myoepithelial cells of all cutaneous mixed tumors. SOX-10 expression on the cells lining the glandular structures in mixed tumors was variable. All myoepitheliomas and mixed tumors were positive for S100 and negative for MiTF. Pan-keratin, HMK903, smooth muscle actin (SMA) and epithelial membrane antigen (EMA) showed variable expression.
SOX-10 is a relatively reliable marker for staining cutaneous myoepitheliomas. Cutaneous myoepitheliomas are notoriously difficult to diagnose, and the addition of SOX-10 to the repertoire of stains that can label this tumor is of practical utility. These results futher support that cutaneous myoepitheliomas and cutaneous mixed tumors exist on a morphologic and immunophenotypic spectrum.

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