To construct reference charts and equations of fetal biometry for singleton pregnant women in Shaanxi, China. Materials and
This was a cross-sectional study involving 6,832 singleton pregnant women. One set of fetal ultrasonographic measurement data between the 16th to 41st gestational weeks (GW) was randomly selected from each pregnant woman, and biparietal diameter (BPD), abdominal circumference (AC), and femur length (FL) were recorded. Mean and standard deviation (SD) of BPD, AC, and FL were fitted by polynomial. Centile = Mean + Z(alpha) x SD was used to calculate centiles. Differences in the 50th centile of BPD, AC, and FL between Hong Kong, Korean, Italian and Shaanxi fetuses were compared.
Mean of BPD, AC, and FL were well-fitted by quadratic polynomial, SD of BPD, AC and FL were fitted by linear regression. Equations for estimating mean and SD for BPD, AC, and FL from GW were obtained. Centiles for BPD,AC, and FL were calculated. From the 21st GW, the differences in BPD,AC, and FL between Hong Kong, Korean, Italian, and Shaanxi fetuses became larger.
Fetal biometry reference charts and equations for estimating fetal size and GW could be used in obstetrics practice and research in Shaanxi, China.
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[Show abstract][Hide abstract] ABSTRACT: Diagnosis of intrauterine fetal growth restriction and prediction of small-for-gestation age are often based on fetal abdominal circumference or estimated fetal weight (EFW). The present study aims to create unconditional (cross-sectional) and conditional (longitudinal) standards of fetal abdominal circumference and EFW for use in an ethnic Chinese population.
In the Growing Up in Singapore Towards healthy Outcome (GUSTO) birth cohort study in Singapore, fetal biometric measurements were obtained at enrolment to antenatal care (11-12 weeks) and up to three more time points during pregnancy. Singleton pregnancies with a healthy profile defined by maternal, pregnancy and fetal characteristics and birth outcomes were selected for this analysis. The Hadlock algorithm was used to calculate EFW. Mixed effects model was used to establish unconditional and conditional standards in z-scores and percentiles for both genders pooled and for each gender separately.
A total of 313 women were included, of whom 294 had 3 and 19 had 2 ultrasound scans other than the gestational age dating scan. Fetal abdominal circumference showed a roughly linear trajectory from 18 to 36 weeks of gestation, while EFW showed an accelerating trajectory. Gender differences were more pronounced in the 10(th) percentile than the 50(th) or 90(th) percentiles. As compared to other published charts, this population showed growth trajectories that started low but caught up at later gestations.
Unconditional and conditional standards for monitoring fetal size and fetal growth in terms of abdominal circumference and EFW are available for this ethnic-Chinese population. Electronic spreadsheets are provided for their implementation.