The Effects of Valerian Root on Hot Flashes in Menopausal Women

Iranian journal of pharmaceutical research (IJPR) (Impact Factor: 1.07). 03/2013; 12(1):217-22.
Source: PubMed


Hot flash is among the most common complaints of menopausal women, affecting their career, social activities and quality of life. This study aimed to investigate the effects of Valerian on hot flashes in menopausal women. In this double blind clinical trial, 68 menopausal women with the chief complaint of hot flash were enrolled using sampling at hand and were randomly divided into drug and placebo groups. The women in the drug group were prescribed 255 mg Valerian capsules 3 times a day for 8 weeks. The women in the placebo group were prescribed identical capsules filled with starch. Then, severity and frequency of hot flashes were measured and recorded through questionnaires and information forms in three levels (2 weeks before, four and eight weeks after the treatment). The Severity of hot flashes revealed a meaningful statistical difference pre- and post- Valerian treatment (p <0.001) while this difference was not meaningful in the placebo group. Further, the comparison of the two groups regarding the severity of hot flash after the treatment showed a meaningful statistical difference (p <0.001). Valerian has also led to a reduction of hot flash frequencies 4 and 8 weeks after the treatment (p <0.001) but this difference was not meaningful in drug like group. Valerian can be effective in treatment of menopausal hot flash and that it can be considered as a treatment of choice for reduction of hot flashes among the women who are reluctant to receive hormone therapy due to fear or any other reason.

Download full-text


Available from: Parvaneh Mirabi, Jul 23, 2014
25 Reads
  • Source
    • "Herbal supplements are widely used for vasomotor symptoms , with varying degrees of efficacy. Among the more frequently studied are hops (Heyerick et al. 2006; Erkkola et al. 2010), red clover (Hidalgo et al. 2005; Geller et al. 2009; Lipovac et al. 2012), flaxseed (Lewis et al. 2006; Colli et al. 2012; Pruthi et al. 2012), St. John's Wort (Hypericum perforatum) (Al-Akoum et al. 2009; Abdali et al. 2010; Uebelhack et al. 2006; Briese et al. 2007), evening primrose (Oenothera biennis) (Farzaneh et al. 2013), French maritime pine bark (Pycngenol) (Yang et al. 2007; Kohama & Negami 2013); Sibiric Rhubarb (Rheum rhaponticum) (Heger et al. 2006; Kaszkin-Bettag et al. 2007; Kaszkin- Bettag et al. 2009; Hasper et al. 2009), valerian root (Valeriana officinalis) (Mirabi & Mojab 2013), Guaraná (Paullinia cupana) (Oliveira et al. 2013), and magnesium (Park et al. 2011). Summaries of these studies can be found in Additional file 1. "
    [Show abstract] [Hide abstract]
    ABSTRACT: The cardinal climacteric symptoms of hot flushes and night sweats affect 24-93% of all women during the physiological transition from reproductive to post-reproductive life. Though efficacious, hormonal therapy and partial oestrogenic compounds are linked to a significant increase in breast cancer. Non-hormonal treatments are thus greatly appreciated. This systematic review of published hormonal and non-hormonal treatments for climacteric, and breast and prostate cancer-associated hot flushes, examines clinical efficacy and therapy-related cancer risk modulation. A PubMed search included literature up to June 19, 2014 without limits for initial dates or language, with the search terms, (hot flush* OR hot flash*) AND (clinical trial* OR clinical stud*) AND (randomi* OR observational) NOT review). Retrieved references identified further papers. The focus was on hot flushes; other symptoms (night sweats, irritability, etc.) were not specifically screened. Included were some 610 clinical studies where a measured effect of the intervention, intensity and severity were documented, and where patients received treatment of pharmaceutical quality. Only 147 of these references described studies with alternative non-hormonal treatments in post-menopausal women and in breast and prostate cancer survivors; these results are presented in Additional file 1. The most effective hot flush treatment is oestrogenic hormones, or a combination of oestrogen and progestins, though benefits are partially outweighed by a significantly increased risk for breast cancer development. This review illustrates that certain non-hormonal treatments, including selective serotonin reuptake inhibitors, gabapentin/pregabalin, and Cimicifuga racemosa extracts, show a positive risk-benefit ratio. Key pointsSeveral non-hormonal alternatives to hormonal therapy have been established and registered for the treatment of vasomotor climacteric symptoms in peri- and post-menopausal women.There are indications that non-hormonal treatments are useful alternatives in patients with a history of breast and prostate cancer. However, confirmation by larger clinical trials is required.
    SpringerPlus 12/2015; 4(1). DOI:10.1186/s40064-015-0808-y
  • Source
    [Show abstract] [Hide abstract]
    ABSTRACT: The Valerian plant is known as a medicinal plant with sedative, anxiolytic, anti-inflammatory properties and somnifacient effect. Therefore studying cardiac effects of this plant can help to gain a better understanding of its pharmacodynamics effects in order to provide above properties. In this research 18 healthy female pet cats, 2 years old in the mean, were selected. Cardiac function indexes including the fractional shortening, ejection fraction and normal stroke volume were measured using echocardiography. Cats were fed by 500 mg/kg Valerian root extract and clinical signs like distraction and incoordination were observed after 15 minutes; the factors were measured. Results were analyzed by the statistical method of independent T-test. Obtained data was showed satisfactory results which are detailed described in the text below. The results showed that stroke volume index increased significantly while fractional shortening index decreased significantly. Also the ejection fraction index was not significant statistically. Therefore extract of the Valerian root decreases the sympathetic performance, effects on the heart indirectly, relaxes the myocardium in result of the decrease in the fractional shortening of the heart muscle and consequently increases the diastolic and systolic volume and increases the stroke volume of the blood accompanied by the decrease in the preload and after load.
    Human and Veterinary Medicine 01/2015; 7(1):27-30.