Correlation of increased PARP14 and CCL26 expression in biopsies from children with eosinophilic esophagitis

Department of Pediatrics, Wells Center for Pediatric Research, Riley Hospital for Children, Indiana University School of Medicine, Indianapolis, Ind.
The Journal of allergy and clinical immunology (Impact Factor: 11.48). 11/2013; 133(2). DOI: 10.1016/j.jaci.2013.09.031
Source: PubMed
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    ABSTRACT: Eosinophilic esophagitis (EoE) is a complex, polygenic disorder caused by genetic predisposition and environmental exposures. Because of the recent emergence of EoE as a bona fide global health concern, a paucity of available therapeutic and diagnostic options exists. However, rapid progress has been made in an effort to rectify this lack and to improve understanding of the factors that cause EoE. This article highlights key advances in elucidating the genetic (and epigenetic) components involved in EoE.
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