The Frustrated Gene: Origins of Eukaryotic Gene Expression

Department of Biochemistry and Biophysics, University of California, San Francisco, San Francisco, CA 94158, USA. Electronic address: .
Cell (Impact Factor: 32.24). 11/2013; 155(4):744-9. DOI: 10.1016/j.cell.2013.10.003
Source: PubMed


Eukarytotic gene expression is frustrated by a series of steps that are generally not observed in prokaryotes and are therefore not essential for the basic chemistry of transcription and translation. Their evolution may have been driven by the need to defend against parasitic nucleic acids.

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